DegronMD

Uniprot ID: Q8WWL7

Source protein: G2/mitotic-specific cyclin-B3

Source gene: CCNB3

Class: DEG_APCC_DBOX_1

Location: 394:402

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8585

ASA_SCORE: 101.5556

COIL: 0.7126

CONS_SCORE: 0.3916

DSS_SCORE: 0.3948

HELIX: 0.066

FCONS_SCORE: 1.0065

RIG_SCORE: 0.7866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G393R	TCGA-21-1082	LUSC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.3056
p.G393R	DO26463	LUSC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.3056
p.R397P	TCGA-33-4538	LUSC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.6401
p.R397P	DO26695	LUSC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.6401
p.E405D	TCGA-AG-A002	READ	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.25
p.S412L	TCGA-AP-A0LM	UCEC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.0556
p.S412L	DO43306	UCEC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.0556
p.R397H	TCGA-D1-A174	UCEC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.7133
p.R397H	TCGA-VS-A9UJ	CESC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.7133
p.R397H	DO219735	CESC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.7133
p.R397H	DO228577	LICA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.7133
p.R397H	DO40900	UCEC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.7133
p.L398V	TCGA-DG-A2KM	CESC	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.6765
p.L398V	DO51597	CESC	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.6765
p.G409E	TCGA-EB-A5FP	SKCM	TCGA	KRSRLKPLV	DEG_APCC_DBOX_1	0.1389
p.G409E	DO47362	SKCM	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.1389
p.K386N	DO229015	LICA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.2222
p.P400T	DO35148	PACA	ICGC	KRSRLKPLV	DEG_APCC_DBOX_1	0.5919
p.V402L	SIDM00683	Prostate Carcinoma	GDSC	KRSRLKPLV	DEG_APCC_DBOX_1	0.5654
p.V402L	ACH-000977	lymph_node	CCLE	KRSRLKPLV	DEG_APCC_DBOX_1	0.5654
p.R397C	SIDM00293	Small Cell Lung Carcinoma	GDSC	KRSRLKPLV	DEG_APCC_DBOX_1	0.719
p.R397C	ACH-002052	Lung Cancer	CCLE	KRSRLKPLV	DEG_APCC_DBOX_1	0.719
p.R397C	LU-139	lung	COSMIC	KRSRLKPLV	DEG_APCC_DBOX_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWL7	G2/mitotic-specific cyclin-B3	DEG_APCC_DBOX_1	394:402	KRSRLKPLV	APC,CDC20,FZR1	0.8585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons