DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_COP1_1

Location: 1023:1034

E3 ligase: COP1

DEGRON score: 0.96

ASA_SCORE: 91.2083

COIL: 0.8013

CONS_SCORE: 0

DSS_SCORE: 0.3398

HELIX: 0.1303

FCONS_SCORE: 0

RIG_SCORE: 0.7232

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1020K	TCGA-56-8625	LUSC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.6944
p.E1020K	DO45515	LUSC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.6944
p.S1027I	TCGA-B5-A1MR	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.7341
p.S1027I	DO41758	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.7341
p.Q1015H	TCGA-BS-A0UV	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.1111
p.Q1015H	DO42793	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.1111
p.W1017C	TCGA-EE-A2GH	SKCM	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.1667
p.W1017C	DO37643	SKCM	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.1667
p.Y1044F	TCGA-EO-A22U	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.0556
p.Y1044F	DO43755	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.0556
p.S1020Y	TCGA-EY-A1GI	UCEC	TCGA	SEDSSFLKVPSV	DEG_COP1_1	0.6944
p.S1020Y	DO36881	READ	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.6944
p.S1020Y	DO41211	UCEC	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.6944
p.D1018G	DO224905	BRCA	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.3056
p.L1016S	DO9700	COAD	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.1389
p.E1024D	DO229024	LICA	ICGC	SEDSSFLKVPSV	DEG_COP1_1	0.5647
p.K1039N	ACH-000623	Brain Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	0.3056
p.N1019Y	ACH-000657	Ovarian Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	0.2222
p.T1014I	ACH-000982	Colon/Colorectal Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	0.0833
p.T1014I	ACH-001345	Colon/Colorectal Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	0.0833
p.E1017G	ACH-001525	Cervical Cancer	CCLE	SEDSSFLKVPSV	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DQ2	Very large A-kinase anchor protein	DEG_COP1_1	1023:1034	SEDSSFLKVPSV	COP1	0.96	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons