DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LSPFIE
Uniprot ID:
Q68DQ2
Source protein:
Very large A-kinase anchor protein
Source gene:
CRYBG3
Class:
LIG_APCC_ABBA_1
Location:
2276:2281
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9959
ASA_SCORE:
64.9167
COIL:
0.7122
CONS_SCORE:
0
DSS_SCORE:
0.415
HELIX:
0.0965
FCONS_SCORE:
0
RIG_SCORE:
0.7716
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y2266C
SIDM01099
Neuroblastoma
GDSC
LSPFIE
LIG_APCC_ABBA_1
0.0556
p.Y2266C
SIDM01664
Prostate Carcinoma
GDSC
LSPFIE
LIG_APCC_ABBA_1
0.0556
Drug responses associated with CRYBG3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LSPFIE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q68DQ2
Very large A-kinase anchor protein
LIG_APCC_ABBA_1
2276:2281
LSPFIE
APC,CDC20,FZR1
0.9959
More...