DegronMD

Uniprot ID: Q68DQ2

Source protein: Very large A-kinase anchor protein

Source gene: CRYBG3

Class: DEG_APCC_KENBOX_2

Location: 903:907

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8895

ASA_SCORE: 99.34

COIL: 0.6402

CONS_SCORE: 0.769

DSS_SCORE: 0.4317

HELIX: 0.262

FCONS_SCORE: 1.0682

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S916Y	TCGA-AP-A059	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.0833
p.S916Y	DO41361	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.0833
p.E905D	TCGA-AP-A1E0	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.6758
p.E905D	DO43154	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.6758
p.L911I	TCGA-AX-A1CE	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.2222
p.L911I	DO42280	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.2222
p.E896Q	TCGA-EK-A2R8	CESC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.1389
p.E896Q	DO51599	CESC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.1389
p.K917E	TCGA-EO-A22R	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.1667
p.K917E	DO42713	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.1667
p.E896D	TCGA-EO-A3AV	UCEC	TCGA	LKENC	DEG_APCC_KENBOX_2	0.1389
p.E896D	DO52412	UCEC	ICGC	LKENC	DEG_APCC_KENBOX_2	0.1389
p.R893I	DO228974	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	0.0556
p.R897L	DO229015	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	0.2778
p.R897L	DO229031	LICA	ICGC	LKENC	DEG_APCC_KENBOX_2	0.2778
p.L911F	DO37659	SKCM	ICGC	LKENC	DEG_APCC_KENBOX_2	0.2222
p.A898T	DO229264	THCA	ICGC	LKENC	DEG_APCC_KENBOX_2	0.1944
p.G900C	ACH-000958	Colon/Colorectal Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	0.25
p.L911R	ACH-001664	Gastric Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	0.2222
p.N896K	ACH-002233	Colon/Colorectal Cancer	CCLE	LKENC	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DQ2	Very large A-kinase anchor protein	DEG_APCC_KENBOX_2	903:907	LKENC	APC,CDC20,FZR1	0.8895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons