DegronMD

Uniprot ID: Q68DE3

Source protein: Basic helix-loop-helix domain-containing protein USF3

Source gene: USF3

Class: DEG_SCF_FBW7_1

Location: 558:565

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 95.3125

COIL: 0.9623

CONS_SCORE: 0.5619

DSS_SCORE: 0.441

HELIX: 0.0108

FCONS_SCORE: 0.8684

RIG_SCORE: 0.7325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N573S	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	PSTTPCPT	DEG_SCF_FBW7_1	0.1111
p.N573S	HOP-92	lung	COSMIC	PSTTPCPT	DEG_SCF_FBW7_1	0.1111
p.P562L	SIDM00515	Melanoma	GDSC	PSTTPCPT	DEG_SCF_FBW7_1	0.7582
p.P562L	COLO-800	skin	COSMIC	PSTTPCPT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SCF_FBW7_1	558:565	PSTTPCPT	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons