DegronMD

Uniprot ID: O94933

Source protein: SLIT and NTRK-like protein 3

Source gene: SLITRK3

Class: DEG_APCC_KENBOX_2

Location: 801:805

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9165

ASA_SCORE: 104.8

COIL: 0.817

CONS_SCORE: 0.4935

DSS_SCORE: 0.5567

HELIX: 0.1502

FCONS_SCORE: 0.864

RIG_SCORE: 0.6766

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L791I	TCGA-35-4122	LUAD	TCGA	PKENH	DEG_APCC_KENBOX_2	0.0556
p.L791I	DO23782	LUAD	ICGC	PKENH	DEG_APCC_KENBOX_2	0.0556
p.L812Q	TCGA-AD-6901	COAD	TCGA	PKENH	DEG_APCC_KENBOX_2	0.1389
p.L812Q	DO9218	COAD	ICGC	PKENH	DEG_APCC_KENBOX_2	0.1389
p.A798V	TCGA-AP-A1DK	UCEC	TCGA	PKENH	DEG_APCC_KENBOX_2	0.25
p.A798V	DO42033	UCEC	ICGC	PKENH	DEG_APCC_KENBOX_2	0.25
p.E803D	TCGA-EO-A22U	UCEC	TCGA	PKENH	DEG_APCC_KENBOX_2	0.6758
p.E803D	DO43755	UCEC	ICGC	PKENH	DEG_APCC_KENBOX_2	0.6758
p.L791F	TCGA-FW-A3R5	SKCM	TCGA	PKENH	DEG_APCC_KENBOX_2	0.0556
p.L791F	DO37406	SKCM	ICGC	PKENH	DEG_APCC_KENBOX_2	0.0556
p.E815Q	TCGA-ZF-AA4V	BLCA	TCGA	PKENH	DEG_APCC_KENBOX_2	0.0556
p.E815Q	DO219087	BLCA	ICGC	PKENH	DEG_APCC_KENBOX_2	0.0556
p.T810I	DO222404	BTCA	ICGC	PKENH	DEG_APCC_KENBOX_2	0.1944
p.E813K	DO6376	CLLE	ICGC	PKENH	DEG_APCC_KENBOX_2	0.1111
p.E815V	DO228278	LICA	ICGC	PKENH	DEG_APCC_KENBOX_2	0.0556
p.KE802KK	DO222753	MELA	ICGC	PKENH	DEG_APCC_KENBOX_2	0.6667
p.E803K	SIDM00082	Melanoma	GDSC	PKENH	DEG_APCC_KENBOX_2	0.7022
p.E803K	ACH-001190	Skin Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	0.7022
p.E803K	SK-MEL-2	skin	COSMIC	PKENH	DEG_APCC_KENBOX_2	0.7022
p.N804I	SIDM00068	Colorectal Carcinoma	GDSC	PKENH	DEG_APCC_KENBOX_2	0.728
p.N804I	ACH-002394	Colon/Colorectal Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	0.728
p.N804I	GEO	large_intestine	COSMIC	PKENH	DEG_APCC_KENBOX_2	0.728
p.L812M	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	0.1389
p.L812M	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	0.1389
p.Q796R	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	0.1944
p.Q796R	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	0.1944
p.Q796K	SIDM01693	B-Lymphoblastic Leukemia	GDSC	PKENH	DEG_APCC_KENBOX_2	0.1944
p.Q796K	ACH-000032	Leukemia	CCLE	PKENH	DEG_APCC_KENBOX_2	0.1944
p.E795K	SIDM01761	Rhabdomyosarcoma	GDSC	PKENH	DEG_APCC_KENBOX_2	0.1667
p.E795K	ACH-000175	Non-Cancerous	CCLE	PKENH	DEG_APCC_KENBOX_2	0.1667
p.N804T	SIDM00159	Biliary Tract Carcinoma	GDSC	PKENH	DEG_APCC_KENBOX_2	0.7055
p.N804T	ACH-000182	Bile Duct Cancer	CCLE	PKENH	DEG_APCC_KENBOX_2	0.7055
p.R809W	ACH-001991	Primary	CCLE	PKENH	DEG_APCC_KENBOX_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENH

Degron related mutations and impact score

Drug responses associated with SLITRK3 mutations

All proteins holding degron of PKENH

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94933	SLIT and NTRK-like protein 3	DEG_APCC_KENBOX_2	801:805	PKENH	APC,CDC20,FZR1	0.9165	More...