DegronMD - Q9Y6X0(SETBP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S869C	TCGA-17-Z042	LUAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.7541
p.A882V	TCGA-19-5956	GBM	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	TCGA-D1-A17Q	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	DO13863	GBM	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	DO41903	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	ACH-002256	Leukemia	CCLE	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.A882V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0833
p.D880N	TCGA-2F-A9KO	BLCA	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.1389
p.D880N	DO51859	BLCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.1389
p.V1280L	TCGA-33-4566	LUSC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.5654
p.V1280L	TCGA-58-8391	LUSC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.5654
p.V1280L	DO26790	LUSC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.5654
p.V1280L	DO45440	LUSC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.5654
p.S295I	TCGA-35-4123	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.1667
p.S295I	DO26394	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.1667
p.S1272T	TCGA-44-2656	LUAD	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation blocking phosphorylation signal	0.6111
p.S1272T	DO26052	LUAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation blocking phosphorylation signal	0.6111
p.G1353C	TCGA-86-8281	LUAD	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.6489
p.G1353C	DO26318	LUAD	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.6489
p.P1364L	TCGA-91-A4BC	LUAD	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.1667
p.P1364L	DO45422	LUAD	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.1667
p.I871T	TCGA-AB-2899	LAML	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.5966
p.I871T	DO21529	LAML	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.5966
p.G870S	TCGA-AP-A0LM	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6993
p.G870S	DO43306	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6993
p.S1287L	TCGA-AP-A0LM	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.S1287L	TCGA-AX-A06F	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.S1287L	DO43306	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.S1287L	DO41752	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.T864M	TCGA-AX-A1CE	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.2222
p.T864M	DO42280	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.2222
p.S1287P	TCGA-AX-A1CE	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.S1287P	DO42280	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2222
p.V1367A	TCGA-B5-A3FA	UCEC	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.0833
p.V1367A	DO52402	UCEC	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.0833
p.N218K	TCGA-B7-A5TJ	STAD	TCGA	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0833
p.N218K	DO222329	STAD	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0833
p.H1339R	TCGA-BG-A0M4	UCEC	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.0556
p.H1339R	DO41686	UCEC	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.0556
p.D868Y	TCGA-CN-6992	HNSC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.7325
p.D868Y	DO14606	HNSC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.7325
p.P299R	TCGA-CR-6474	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778
p.P299R	DO14542	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778
p.E863D	TCGA-DK-A3IV	BLCA	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.1944
p.E863D	DO467	BLCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.1944
p.S298L	TCGA-DK-A3WW	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.S298L	DO481	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.D868N	TCGA-E6-A1LX	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6932
p.D868N	DO52739	CMDI	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6932
p.D868N	DO224665	LAML	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6932
p.D868N	DO48893	PBCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6932
p.D868N	DO41020	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation altering degron motif	0.6932
p.T1273M	TCGA-EO-A22U	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation blocking phosphorylation signal	0.6389
p.T1273M	DO43755	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation blocking phosphorylation signal	0.6389
p.M220V	TCGA-FI-A2F4	UCEC	TCGA	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1389
p.M220V	DO43434	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1389
p.E858K	TCGA-FW-A3R5	SKCM	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0556
p.E858K	TCGA-L5-A8NV	ESCA	TCGA	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0556
p.E858K	DO220856	MELA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0556
p.E858K	DO37406	SKCM	ICGC	DSGIGT	DEG_SCF_TRCP1_1	868:873	Mutation rewiring degron network	0.0556
p.N1351T	TCGA-L5-A4OT	ESCA	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.5944
p.N1351T	DO233166	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.5944
p.G1268V	TCGA-MP-A4TK	LUAD	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.G1268V	DO45384	LUAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.S1282R	TCGA-WE-AAA0	SKCM	TCGA	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.6316
p.S1282R	DO51294	SKCM	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation altering degron motif	0.6316
p.E1352K	TCGA-Z2-AA3V	SKCM	TCGA	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.7022
p.E1352K	DO222708	MELA	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.7022
p.E1352K	DO51303	SKCM	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.7022
p.W238L	DO10132	COAD	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1667
p.A222T	DO229013	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.A222T	DO229016	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.A222T	DO229005	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.A222T	DO229489	LAML	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.H1348R	DO50340	ESAD	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.3056
p.G1268R	DO234464	ESAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.G1268R	DO35083	PACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.G1268R	ACH-001410	Bladder Cancer	CCLE	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.N1351K	DO233166	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation altering degron motif	0.5806
p.A1366E	DO233728	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.1111
p.K223N	DO233733	GACA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.2222
p.D1289N	DO233845	GACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.1667
p.E1276D	DO233941	GACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.2778
p.G225C	DO228952	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.2778
p.V231F	DO228952	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation altering degron motif	0.5957
p.W222C	DO229029	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.G229V	DO229032	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation altering degron motif	0.7532
p.E240D	DO229041	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1111
p.S1293G	DO44883	LIHC	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.0556
p.P221A	DO231658	LINC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1667
p.H219R	DO45299	LIRI	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1111
p.F220I	DO232855	NACA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1389
p.P1286S	DO27943	ORCA	ICGC	LDVFSE	LIG_APCC_ABBA_1	1278:1283	Mutation rewiring degron network	0.25
p.P313T	DO33600	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.1111
p.V231I	DO232975	PEME	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation altering degron motif	0.5965
p.S305F	DO218847	SKCA	ICGC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.7982
p.A239T	DO41542	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1389
p.S233G	DO43875	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.3056
p.K1363T	SIDM01296	Esophageal Carcinoma	GDSC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation substituting flanking lysine	0.3056
p.W222S	SIDM00282	Colorectal Carcinoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.W222S	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.W222S	CW-2	large intestine	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.1944
p.S233R	SIDM00251	Gastric Carcinoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.3056
p.R217W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0556
p.R217W	PF-382	haematopoietic and lymphoid tissue	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0556
p.G242D	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0556
p.G242D	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.0556
p.S297N	SIDM01608	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2222
p.S297N	ACH-000990	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2222
p.T1360I	SIDM01577	Plasma Cell Myeloma	GDSC	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.2778
p.T1360I	ACH-000889	Myeloma	CCLE	SKNEGSVPTM	DEG_COP1_1	1349:1358	Mutation rewiring degron network	0.2778
p.Q233R	ACH-001097	Lymphoma	CCLE	DSGPVT	DEG_SCF_TRCP1_1	227:232	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SETBP1

UniProt ID: Q9Y6X0

Entrez ID: 26040

Protein name: SET-binding protein (SEB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SETBP1 in