DegronMD

Uniprot ID: Q9Y6X0

Source protein: SET-binding protein

Source gene: SETBP1

Class: DEG_SCF_TRCP1_1

Location: 227:232

E3 ligase: BTRC

DEGRON score: 0.8174

ASA_SCORE: 87.9

COIL: 0.9303

CONS_SCORE: 0.7731

DSS_SCORE: 0.5512

HELIX: 0.038

FCONS_SCORE: 1.0251

RIG_SCORE: 0.6219

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N218K	TCGA-B7-A5TJ	STAD	TCGA	DSGPVT	DEG_SCF_TRCP1_1	0.0833
p.N218K	DO222329	STAD	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.0833
p.M220V	TCGA-FI-A2F4	UCEC	TCGA	DSGPVT	DEG_SCF_TRCP1_1	0.1389
p.M220V	DO43434	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1389
p.W238L	DO10132	COAD	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1667
p.A222T	DO229013	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.A222T	DO229016	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.A222T	DO229005	COCA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.A222T	DO229489	LAML	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.K223N	DO233733	GACA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.2222
p.G225C	DO228952	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.2778
p.V231F	DO228952	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.5957
p.W222C	DO229029	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.G229V	DO229032	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.7532
p.E240D	DO229041	LICA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1111
p.P221A	DO231658	LINC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1667
p.H219R	DO45299	LIRI	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1111
p.F220I	DO232855	NACA	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1389
p.V231I	DO232975	PEME	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.5965
p.A239T	DO41542	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.1389
p.S233G	DO43875	UCEC	ICGC	DSGPVT	DEG_SCF_TRCP1_1	0.3056
p.W222S	SIDM00282	Colorectal Carcinoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.W222S	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.W222S	CW-2	large_intestine	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	0.1944
p.S233R	SIDM00251	Gastric Carcinoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	0.3056
p.R217W	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGPVT	DEG_SCF_TRCP1_1	0.0556
p.R217W	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	0.0556
p.G242D	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGPVT	DEG_SCF_TRCP1_1	0.0556
p.G242D	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPVT	DEG_SCF_TRCP1_1	0.0556
p.Q233R	ACH-001097	Lymphoma	CCLE	DSGPVT	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPVT

Degron related mutations and impact score

Drug responses associated with SETBP1 mutations

All proteins holding degron of DSGPVT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6X0	SET-binding protein	DEG_SCF_TRCP1_1	227:232	DSGPVT	BTRC	0.8174	More...