DegronMD

Uniprot ID: Q9Y6X0

Source protein: SET-binding protein

Source gene: SETBP1

Class: LIG_APCC_ABBA_1

Location: 1278:1283

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9749

ASA_SCORE: 76.2167

COIL: 0.5112

CONS_SCORE: 0.6298

DSS_SCORE: 0.5833

HELIX: 0.4373

FCONS_SCORE: 1.1181

RIG_SCORE: 0.7514

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1280L	TCGA-33-4566	LUSC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.5654
p.V1280L	TCGA-58-8391	LUSC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.5654
p.V1280L	DO26790	LUSC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.5654
p.V1280L	DO45440	LUSC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.5654
p.S1272T	TCGA-44-2656	LUAD	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.6111
p.S1272T	DO26052	LUAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.6111
p.S1287L	TCGA-AP-A0LM	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.S1287L	TCGA-AX-A06F	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.S1287L	DO43306	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.S1287L	DO41752	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.S1287P	TCGA-AX-A1CE	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.S1287P	DO42280	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.2222
p.T1273M	TCGA-EO-A22U	UCEC	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.6389
p.T1273M	DO43755	UCEC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.6389
p.G1268V	TCGA-MP-A4TK	LUAD	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.G1268V	DO45384	LUAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.S1282R	TCGA-WE-AAA0	SKCM	TCGA	LDVFSE	LIG_APCC_ABBA_1	0.6316
p.S1282R	DO51294	SKCM	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.6316
p.G1268R	DO234464	ESAD	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.G1268R	DO35083	PACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.G1268R	ACH-001410	Bladder Cancer	CCLE	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.D1289N	DO233845	GACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.1667
p.E1276D	DO233941	GACA	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.2778
p.S1293G	DO44883	LIHC	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.0556
p.P1286S	DO27943	ORCA	ICGC	LDVFSE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6X0	SET-binding protein	LIG_APCC_ABBA_1	1278:1283	LDVFSE	APC,CDC20,FZR1	0.9749	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons