DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGIGT
Uniprot ID:
Q9Y6X0
Source protein:
SET-binding protein
Source gene:
SETBP1
Class:
DEG_SCF_TRCP1_1
Location:
868:873
E3 ligase:
BTRC
DEGRON score:
0.9488
ASA_SCORE:
70.4833
COIL:
0.904
CONS_SCORE:
1
DSS_SCORE:
0.7225
HELIX:
0.0325
FCONS_SCORE:
1.0027
RIG_SCORE:
0.5753
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S869C
TCGA-17-Z042
LUAD
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.7541
p.A882V
TCGA-19-5956
GBM
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
TCGA-D1-A17Q
UCEC
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
DO13863
GBM
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
DO41903
UCEC
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
SIDM01007
T-Lymphoblastic Leukemia
GDSC
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
ACH-002256
Leukemia
CCLE
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.A882V
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
DSGIGT
DEG_SCF_TRCP1_1
0.0833
p.D880N
TCGA-2F-A9KO
BLCA
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.1389
p.D880N
DO51859
BLCA
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.1389
p.I871T
TCGA-AB-2899
LAML
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.5966
p.I871T
DO21529
LAML
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.5966
p.G870S
TCGA-AP-A0LM
UCEC
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.6993
p.G870S
DO43306
UCEC
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.6993
p.T864M
TCGA-AX-A1CE
UCEC
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.2222
p.T864M
DO42280
UCEC
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.2222
p.D868Y
TCGA-CN-6992
HNSC
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.7325
p.D868Y
DO14606
HNSC
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.7325
p.E863D
TCGA-DK-A3IV
BLCA
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.1944
p.E863D
DO467
BLCA
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.1944
p.D868N
TCGA-E6-A1LX
UCEC
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.6932
p.D868N
DO52739
CMDI
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.6932
p.D868N
DO224665
LAML
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.6932
p.D868N
DO48893
PBCA
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.6932
p.D868N
DO41020
UCEC
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.6932
p.E858K
TCGA-FW-A3R5
SKCM
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.0556
p.E858K
TCGA-L5-A8NV
ESCA
TCGA
DSGIGT
DEG_SCF_TRCP1_1
0.0556
p.E858K
DO220856
MELA
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.0556
p.E858K
DO37406
SKCM
ICGC
DSGIGT
DEG_SCF_TRCP1_1
0.0556
Drug responses associated with SETBP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGIGT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9HCH0
Nck-associated protein 5-like
DEG_SCF_TRCP1_1
1123:1128
DSGIGT
BTRC
0.9892
More...
Q9NR48
Histone-lysine N-methyltransferase ASH1L
DEG_SCF_TRCP1_1
1200:1205
DSGIGT
BTRC
0.9795
More...
Q9Y6X0
SET-binding protein
DEG_SCF_TRCP1_1
868:873
DSGIGT
BTRC
0.9488
More...
O14513
Nck-associated protein 5
DEG_SCF_TRCP1_1
1719:1724
DSGIGT
BTRC
0.9843
More...