DegronMD

Uniprot ID: Q9NR48

Source protein: Histone-lysine N-methyltransferase ASH1L

Source gene: ASH1L

Class: DEG_SCF_TRCP1_1

Location: 1200:1205

E3 ligase: BTRC

DEGRON score: 0.9795

ASA_SCORE: 66.25

COIL: 0.8588

CONS_SCORE: 0.423

DSS_SCORE: 0.7106

HELIX: 0.0422

FCONS_SCORE: 1.0789

RIG_SCORE: 0.5637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1194N	TCGA-AC-A23H	BRCA	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.1667
p.D1194N	DO2401	BRCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.1667
p.E1215D	TCGA-BB-4223	HNSC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	TCGA-BG-A0VX	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	TCGA-D1-A103	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	TCGA-EO-A22X	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	DO15607	HNSC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	DO42312	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	DO43923	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.E1215D	DO43907	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.0556
p.N1207T	TCGA-CA-6717	COAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.2778
p.N1207T	DO8264	COAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.2778
p.S1209N	TCGA-EY-A1GI	UCEC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.2222
p.S1209N	DO41211	UCEC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.2222
p.H1192Y	TCGA-FD-A3NA	BLCA	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.1111
p.H1192Y	DO602	BLCA	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.1111
p.P1198T	TCGA-GJ-A3OU	LIHC	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.2778
p.P1198T	DO223913	LIHC	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.2778
p.D1206V	TCGA-HU-A4G8	STAD	TCGA	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.D1206V	DO47819	STAD	ICGC	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.S1199G	SIDM00680	Colorectal Carcinoma	GDSC	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.S1199G	ACH-000957	Colon/Colorectal Cancer	CCLE	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.S1199G	LS-180	large_intestine	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.D1206Y	SIDM00660	Colorectal Carcinoma	GDSC	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.D1206Y	ACH-000985	Colon/Colorectal Cancer	CCLE	DSGIGT	DEG_SCF_TRCP1_1	0.3056
p.D1206Y	LS-411N	large_intestine	COSMIC	DSGIGT	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCH0	Nck-associated protein 5-like	DEG_SCF_TRCP1_1	1123:1128	DSGIGT	BTRC	0.9892	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SCF_TRCP1_1	1200:1205	DSGIGT	BTRC	0.9795	More...
Q9Y6X0	SET-binding protein	DEG_SCF_TRCP1_1	868:873	DSGIGT	BTRC	0.9488	More...
O14513	Nck-associated protein 5	DEG_SCF_TRCP1_1	1719:1724	DSGIGT	BTRC	0.9843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGIGT

Degron related mutations and impact score

Drug responses associated with ASH1L mutations

All proteins holding degron of DSGIGT