DegronMD

Uniprot ID: Q9Y6X0

Source protein: SET-binding protein

Source gene: SETBP1

Class: DEG_COP1_1

Location: 1349:1358

E3 ligase: COP1

DEGRON score: 0.7822

ASA_SCORE: 86.06

COIL: 0.8144

CONS_SCORE: 0.5239

DSS_SCORE: 0.6133

HELIX: 0.1396

FCONS_SCORE: 0.7897

RIG_SCORE: 0.654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1353C	TCGA-86-8281	LUAD	TCGA	SKNEGSVPTM	DEG_COP1_1	0.6489
p.G1353C	DO26318	LUAD	ICGC	SKNEGSVPTM	DEG_COP1_1	0.6489
p.P1364L	TCGA-91-A4BC	LUAD	TCGA	SKNEGSVPTM	DEG_COP1_1	0.1667
p.P1364L	DO45422	LUAD	ICGC	SKNEGSVPTM	DEG_COP1_1	0.1667
p.V1367A	TCGA-B5-A3FA	UCEC	TCGA	SKNEGSVPTM	DEG_COP1_1	0.0833
p.V1367A	DO52402	UCEC	ICGC	SKNEGSVPTM	DEG_COP1_1	0.0833
p.H1339R	TCGA-BG-A0M4	UCEC	TCGA	SKNEGSVPTM	DEG_COP1_1	0.0556
p.H1339R	DO41686	UCEC	ICGC	SKNEGSVPTM	DEG_COP1_1	0.0556
p.N1351T	TCGA-L5-A4OT	ESCA	TCGA	SKNEGSVPTM	DEG_COP1_1	0.5944
p.N1351T	DO233166	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	0.5944
p.E1352K	TCGA-Z2-AA3V	SKCM	TCGA	SKNEGSVPTM	DEG_COP1_1	0.7022
p.E1352K	DO222708	MELA	ICGC	SKNEGSVPTM	DEG_COP1_1	0.7022
p.E1352K	DO51303	SKCM	ICGC	SKNEGSVPTM	DEG_COP1_1	0.7022
p.H1348R	DO50340	ESAD	ICGC	SKNEGSVPTM	DEG_COP1_1	0.3056
p.N1351K	DO233166	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	0.5806
p.A1366E	DO233728	GACA	ICGC	SKNEGSVPTM	DEG_COP1_1	0.1111
p.K1363T	SIDM01296	Esophageal Carcinoma	GDSC	SKNEGSVPTM	DEG_COP1_1	0.3056
p.T1360I	SIDM01577	Plasma Cell Myeloma	GDSC	SKNEGSVPTM	DEG_COP1_1	0.2778
p.T1360I	ACH-000889	Myeloma	CCLE	SKNEGSVPTM	DEG_COP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6X0	SET-binding protein	DEG_COP1_1	1349:1358	SKNEGSVPTM	COP1	0.7822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons