DegronMD

Uniprot ID: O14513

Source protein: Nck-associated protein 5

Source gene: NCKAP5

Class: DEG_SCF_FBW7_1

Location: 1063:1069

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 101.3143

COIL: 0.9564

CONS_SCORE: 0.5714

DSS_SCORE: 0.8018

HELIX: 0.0181

FCONS_SCORE: 1.1429

RIG_SCORE: 0.6523

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1064R	TCGA-43-A56U	LUSC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.6218
p.Q1064R	DO49083	LUSC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.6218
p.L1076M	TCGA-50-5933	LUAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.L1076M	DO24800	LUAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.G1062V	TCGA-64-5781	LUAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.3056
p.G1062V	DO23740	LUAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.3056
p.T1079M	TCGA-77-7337	LUSC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	TCGA-DU-6392	LGG	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	TCGA-WS-AB45	COAD	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	DO51734	COAD	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	DO222881	COCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	DO22237	LGG	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.T1079M	DO27445	LUSC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.0556
p.L1076P	TCGA-AG-3906	READ	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.L1076P	DO36491	READ	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.T1056S	TCGA-BS-A0WQ	UCEC	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.T1056S	DO42705	UCEC	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.M1078I	TCGA-DA-A1HY	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.0833
p.M1078I	DO37409	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.0833
p.E1077K	TCGA-FR-A726	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.1111
p.E1077K	DO48665	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1111
p.D1060N	TCGA-FR-A726	SKCM	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.D1060N	DO48665	SKCM	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.E1074K	TCGA-XX-A899	BRCA	TCGA	LQTPRIS	DEG_SCF_FBW7_1	0.1944
p.E1074K	DO51228	BRCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1944
p.I1068F	DO222446	ESCA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.6304
p.T1056N	DO229018	LICA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1389
p.D1060E	DO229031	LICA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.G1055E	DO222875	MELA	ICGC	LQTPRIS	DEG_SCF_FBW7_1	0.1111
p.I1061M	SIDM01007	T-Lymphoblastic Leukemia	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.2778
p.I1061M	ACH-002256	Leukemia	CCLE	LQTPRIS	DEG_SCF_FBW7_1	0.2778
p.I1061M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPRIS	DEG_SCF_FBW7_1	0.2778
p.D1060H	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.D1060H	SIDM00863	Burkitt's Lymphoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.T1072N	SIDM00940	Breast Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.T1072N	ACH-000212	Breast Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	0.25
p.P1070S	SIDM01059	Melanoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.3056
p.P1070S	ACH-000915	Skin Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	0.3056
p.P1070S	IPC-298	skin	COSMIC	LQTPRIS	DEG_SCF_FBW7_1	0.3056
p.Q1064H	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LQTPRIS	DEG_SCF_FBW7_1	0.647
p.Q1064H	ACH-000553	Lung Cancer	CCLE	LQTPRIS	DEG_SCF_FBW7_1	0.647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LQTPRIS

Degron related mutations and impact score

Drug responses associated with NCKAP5 mutations

All proteins holding degron of LQTPRIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14513	Nck-associated protein 5	DEG_SCF_FBW7_1	1063:1069	LQTPRIS	FBXW7	0.9908	More...