DegronMD

Uniprot ID: Q9H4W6

Source protein: Transcription factor COE3

Source gene: EBF3

Class: DEG_SCF_FBW7_1

Location: 474:481

E3 ligase: FBXW7

DEGRON score: 0.9654

ASA_SCORE: 80.0125

COIL: 0.8873

CONS_SCORE: 0.3311

DSS_SCORE: 0.5982

HELIX: 0.0495

FCONS_SCORE: 1.0173

RIG_SCORE: 0.6365

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q470K	TCGA-55-8507	LUAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.2222
p.A488T	TCGA-A5-A0G2	UCEC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.1389
p.A488T	TCGA-BR-7704	STAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.1389
p.A488T	TCGA-FG-A6J1	LGG	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.1389
p.A490V	TCGA-AA-3864	COAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.0833
p.V464I	TCGA-D1-A103	UCEC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.V464I	TCGA-IN-A6RI	STAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.P469L	TCGA-DX-A8BP	SARC	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.1944
p.S491I	TCGA-G4-6628	COAD	TCGA	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.R470Q	DO51612	CESC	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.2222
p.T488N	DO229029	LICA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.1389
p.T485K	DO229008	LICA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.2222
p.Q479K	DO45412	LUAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.5833
p.V467L	DO24760	LUAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.1389
p.T477A	DO232007	ORCA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.7139
p.S475I	DO231284	PACA	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.623
p.P478L	DO220056	SARC	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.7582
p.N482S	DO47811	STAD	ICGC	PSSTPQQS	DEG_SCF_FBW7_1	0.3056
p.S491N	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	SIDM00461	Acute Myeloid Leukemia	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	SIDM01519	Head and Neck Carcinoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.S491N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	0.0556
p.M481I	SIDM00011	Melanoma	GDSC	PSSTPQQS	DEG_SCF_FBW7_1	0.7618
p.M490I	ACH-000477	Skin Cancer	CCLE	PSSTPQQS	DEG_SCF_FBW7_1	0.0833
p.S465N	ACH-000919	Gastric Cancer	CCLE	PSSTPQQS	DEG_SCF_FBW7_1	0.0833
p.S465N	IM-95	stomach	COSMIC	PSSTPQQS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPQQS

Degron related mutations and impact score

Drug responses associated with EBF3 mutations

All proteins holding degron of PSSTPQQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4W6	Transcription factor COE3	DEG_SCF_FBW7_1	474:481	PSSTPQQS	FBXW7	0.9654	More...