DegronMD

Uniprot ID: Q5T8P6

Source protein: RNA-binding protein 26

Source gene: RBM26

Class: DEG_COP1_1

Location: 398:406

E3 ligase: COP1

DEGRON score: 0.9922

ASA_SCORE: 65.0778

COIL: 0.9194

CONS_SCORE: 0.2475

DSS_SCORE: 0.6471

HELIX: 0.0513

FCONS_SCORE: 0.775

RIG_SCORE: 0.5963

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S390C	TCGA-53-7624	LUAD	TCGA	SATSSVPTV	DEG_COP1_1	0.1111
p.S390C	DO25058	LUAD	ICGC	SATSSVPTV	DEG_COP1_1	0.1111
p.P416S	TCGA-CQ-5326	HNSC	TCGA	SATSSVPTV	DEG_COP1_1	0.0556
p.P416S	DO15286	HNSC	ICGC	SATSSVPTV	DEG_COP1_1	0.0556
p.P396L	TCGA-GN-A26C	SKCM	TCGA	SATSSVPTV	DEG_COP1_1	0.2778
p.P396L	DO37782	SKCM	ICGC	SATSSVPTV	DEG_COP1_1	0.2778
p.P389L	TCGA-UU-A93S	BRCA	TCGA	SATSSVPTV	DEG_COP1_1	0.0833
p.P389L	DO219645	BRCA	ICGC	SATSSVPTV	DEG_COP1_1	0.0833
p.A399S	DO225249	BRCA	ICGC	SATSSVPTV	DEG_COP1_1	0.6477
p.S402Y	DO228952	LICA	ICGC	SATSSVPTV	DEG_COP1_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8P6	RNA-binding protein 26	DEG_COP1_1	398:406	SATSSVPTV	COP1	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons