DegronMD

Uniprot ID: Q5T8P6

Source protein: RNA-binding protein 26

Source gene: RBM26

Class: LIG_APCC_ABBA_1

Location: 97:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 97.8

COIL: 0.6983

CONS_SCORE: 0.3987

DSS_SCORE: 0.5293

HELIX: 0.2755

FCONS_SCORE: 1.1097

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E96D	TCGA-AA-3815	COAD	TCGA	FFPHQE	LIG_APCC_ABBA_1	0.3056
p.E96D	DO9924	COAD	ICGC	FFPHQE	LIG_APCC_ABBA_1	0.3056
p.D104Y	TCGA-B5-A11N	UCEC	TCGA	FFPHQE	LIG_APCC_ABBA_1	0.2778
p.D104Y	DO41458	UCEC	ICGC	FFPHQE	LIG_APCC_ABBA_1	0.2778
p.D104N	TCGA-CV-7568	HNSC	TCGA	FFPHQE	LIG_APCC_ABBA_1	0.2778
p.D104N	DO14160	HNSC	ICGC	FFPHQE	LIG_APCC_ABBA_1	0.2778
p.G91E	TCGA-YD-A89C	SKCM	TCGA	FFPHQE	LIG_APCC_ABBA_1	0.1667
p.G91E	DO219501	SKCM	ICGC	FFPHQE	LIG_APCC_ABBA_1	0.1667
p.P99A	SIDM00719	Small Cell Lung Carcinoma	GDSC	FFPHQE	LIG_APCC_ABBA_1	0.7503
p.P99A	ACH-001364	Lung Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	0.7503
p.P99A	NCI-H345	lung	COSMIC	FFPHQE	LIG_APCC_ABBA_1	0.7503
p.S89L	ACH-000975	Lung Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	0.1111
p.P99L	ACH-001791	Liposarcoma	CCLE	FFPHQE	LIG_APCC_ABBA_1	0.6471
p.E102D	ACH-002834	Bone Cancer	CCLE	FFPHQE	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8P6	RNA-binding protein 26	LIG_APCC_ABBA_1	97:102	FFPHQE	APC,CDC20,FZR1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons