DegronMD

Uniprot ID: Q5T8P6

Source protein: RNA-binding protein 26

Source gene: RBM26

Class: DEG_APCC_DBOX_1

Location: 455:463

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9841

ASA_SCORE: 83.6778

COIL: 0.91

CONS_SCORE: 0.4226

DSS_SCORE: 0.5926

HELIX: 0.0523

FCONS_SCORE: 1.2975

RIG_SCORE: 0.6736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R456M	TCGA-AP-A1DK	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.8632
p.R456M	DO232224	PBCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.8632
p.R456M	DO42033	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.8632
p.R472I	TCGA-B5-A11E	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.0833
p.R472I	TCGA-EO-A22R	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.0833
p.R472I	DO41644	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.0833
p.R472I	DO42713	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.0833
p.V452M	TCGA-BS-A0UF	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.25
p.V452M	DO41488	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.25
p.D468N	TCGA-DF-A2KU	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.1944
p.D468N	DO223286	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1944
p.L462I	DO228976	LICA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.6063
p.S449F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1667
p.S449F	NCI-H1770	lung	COSMIC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons