DegronMD - Q9P2N5(RBM27)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L926P	TCGA-25-2400	OV	TCGA	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.7582
p.L926P	DO28053	OV	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.7582
p.H973L	TCGA-94-8490	LUSC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.25
p.H973L	DO52021	LUSC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.25
p.A934V	TCGA-A2-A25B	BRCA	TCGA	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation rewiring degron network	0.2222
p.A934V	DO2706	BRCA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation rewiring degron network	0.2222
p.G959E	TCGA-AA-3531	COAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.25
p.G959E	DO9948	COAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.25
p.R515C	TCGA-AP-A0LM	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.8301
p.R515C	DO43306	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation altering degron motif	0.8301
p.R510I	TCGA-B5-A0JY	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.R510I	DO43041	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2222
p.R958C	TCGA-B5-A3FC	UCEC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.R958C	DO41871	UCEC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.R974H	TCGA-EO-A22U	UCEC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.R974H	TCGA-IB-7651	PAAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.R974H	DO46657	PAAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.R974H	DO43755	UCEC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.Q512K	TCGA-FS-A1ZA	SKCM	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2778
p.Q512K	DO37551	SKCM	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2778
p.G960V	TCGA-PE-A5DC	BRCA	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2778
p.G960V	DO219641	BRCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2778
p.S523F	TCGA-SY-A9G5	BLCA	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.3056
p.S523F	DO51906	BLCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.3056
p.V980D	TCGA-VQ-A91Q	STAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.0556
p.V980D	DO51786	STAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.0556
p.R923Q	DO233706	GACA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.7329
p.S963Y	DO14718	HNSC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation altering degron motif	0.712
p.G937C	DO228952	LICA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation rewiring degron network	0.1389
p.G964V	DO229037	LICA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation altering degron motif	0.6421
p.G964V	DO229045	LICA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation altering degron motif	0.6421
p.L922V	DO228906	LICA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.5654
p.S965F	DO222837	MELA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation altering degron motif	0.6871
p.E921D	DO222843	MELA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation rewiring degron network	0.3056
p.R956Q	DO229494	SKCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.1667
p.R956Q	DO218849	SKCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.1667
p.Q512H	DO218900	SKCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.2778
p.P976S	DO37782	SKCM	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation substituting flanking lysine	0.2778
p.H968N	DO229229	THCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation altering degron motif	0.6312
p.S509L	SIDM01048	Plasma Cell Myeloma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1944
p.S509L	ACH-000821	Myeloma	CCLE	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1944
p.S509L	EJM	haematopoietic and lymphoid tissue	COSMIC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1944
p.V528A	SIDM00845	Burkitt's Lymphoma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation rewiring degron network	0.1667
p.R958H	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRGSLNHMV	DEG_APCC_DBOX_1	962:970	Mutation rewiring degron network	0.2222
p.K925Q	SIDM01611	Endometrial Carcinoma	GDSC	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.5833
p.K925Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	LRKKLSQLQ	DEG_APCC_DBOX_1	922:930	Mutation altering degron motif	0.5833
p.T513S	ACH-000578	Lung Cancer	CCLE	QRPNLIGLT	DEG_APCC_DBOX_1	514:522	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM27

UniProt ID: Q9P2N5

Entrez ID: 54439

Protein name: RNA-binding protein 27 (RNA-binding motif protein 27)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM27 in