DegronMD

Uniprot ID: Q9P2N5

Source protein: RNA-binding protein 27

Source gene: RBM27

Class: DEG_APCC_DBOX_1

Location: 922:930

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8836

ASA_SCORE: 69.1556

COIL: 0.0308

CONS_SCORE: 0.3505

DSS_SCORE: 0.4202

HELIX: 0.9692

FCONS_SCORE: 1.0875

RIG_SCORE: 0.8048

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L926P	TCGA-25-2400	OV	TCGA	LRKKLSQLQ	DEG_APCC_DBOX_1	0.7582
p.L926P	DO28053	OV	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.7582
p.R923Q	DO233706	GACA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.7329
p.K925Q	SIDM01611	Endometrial Carcinoma	GDSC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.5833
p.K925Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	LRKKLSQLQ	DEG_APCC_DBOX_1	0.5833
p.L922V	DO228906	LICA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.5654
p.E921D	DO222843	MELA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.3056
p.A934V	TCGA-A2-A25B	BRCA	TCGA	LRKKLSQLQ	DEG_APCC_DBOX_1	0.2222
p.A934V	DO2706	BRCA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.2222
p.G937C	DO228952	LICA	ICGC	LRKKLSQLQ	DEG_APCC_DBOX_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2N5	RNA-binding protein 27	DEG_APCC_DBOX_1	922:930	LRKKLSQLQ	APC,CDC20,FZR1	0.8836	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons