DegronMD

Uniprot ID: Q9P2N5

Source protein: RNA-binding protein 27

Source gene: RBM27

Class: DEG_APCC_DBOX_1

Location: 514:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 69.9

COIL: 0.8642

CONS_SCORE: 0.2761

DSS_SCORE: 0.5648

HELIX: 0.0484

FCONS_SCORE: 1.1038

RIG_SCORE: 0.7273

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R515C	TCGA-AP-A0LM	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.8301
p.R515C	DO43306	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.8301
p.R510I	TCGA-B5-A0JY	UCEC	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.2222
p.R510I	DO43041	UCEC	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.2222
p.Q512K	TCGA-FS-A1ZA	SKCM	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.2778
p.Q512K	DO37551	SKCM	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.2778
p.S523F	TCGA-SY-A9G5	BLCA	TCGA	QRPNLIGLT	DEG_APCC_DBOX_1	0.3056
p.S523F	DO51906	BLCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.3056
p.Q512H	DO218900	SKCA	ICGC	QRPNLIGLT	DEG_APCC_DBOX_1	0.2778
p.S509L	SIDM01048	Plasma Cell Myeloma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1944
p.S509L	ACH-000821	Myeloma	CCLE	QRPNLIGLT	DEG_APCC_DBOX_1	0.1944
p.S509L	EJM	haematopoietic_and_lymphoid_tissue	COSMIC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1944
p.V528A	SIDM00845	Burkitt's Lymphoma	GDSC	QRPNLIGLT	DEG_APCC_DBOX_1	0.1667
p.T513S	ACH-000578	Lung Cancer	CCLE	QRPNLIGLT	DEG_APCC_DBOX_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons