DegronMD

Uniprot ID: Q9P2N5

Source protein: RNA-binding protein 27

Source gene: RBM27

Class: DEG_APCC_DBOX_1

Location: 962:970

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9817

ASA_SCORE: 74.6

COIL: 0.7057

CONS_SCORE: 0.2912

DSS_SCORE: 0.6426

HELIX: 0.0809

FCONS_SCORE: 0.6587

RIG_SCORE: 0.6277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H973L	TCGA-94-8490	LUSC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.25
p.H973L	DO52021	LUSC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.25
p.G959E	TCGA-AA-3531	COAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.25
p.G959E	DO9948	COAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.25
p.R958C	TCGA-B5-A3FC	UCEC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.R958C	DO41871	UCEC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.R974H	TCGA-EO-A22U	UCEC	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.R974H	TCGA-IB-7651	PAAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.R974H	DO46657	PAAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.R974H	DO43755	UCEC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222
p.G960V	TCGA-PE-A5DC	BRCA	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.2778
p.G960V	DO219641	BRCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2778
p.V980D	TCGA-VQ-A91Q	STAD	TCGA	GRGSLNHMV	DEG_APCC_DBOX_1	0.0556
p.V980D	DO51786	STAD	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.0556
p.S963Y	DO14718	HNSC	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.712
p.G964V	DO229037	LICA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.6421
p.G964V	DO229045	LICA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.6421
p.S965F	DO222837	MELA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.6871
p.R956Q	DO229494	SKCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.1667
p.R956Q	DO218849	SKCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.1667
p.P976S	DO37782	SKCM	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2778
p.H968N	DO229229	THCA	ICGC	GRGSLNHMV	DEG_APCC_DBOX_1	0.6312
p.R958H	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	GRGSLNHMV	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2N5	RNA-binding protein 27	DEG_APCC_DBOX_1	962:970	GRGSLNHMV	APC,CDC20,FZR1	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons