DegronMD

Uniprot ID: Q9UNZ2

Source protein: NSFL1 cofactor p47

Source gene: NSFL1C

Class: DEG_Kelch_Keap1_1

Location: 192:197

E3 ligase: KEAP1

DEGRON score: 0.9979

ASA_SCORE: 73.2333

COIL: 0.818

CONS_SCORE: 0.8455

DSS_SCORE: 0.2733

HELIX: 0.0372

FCONS_SCORE: 1.1157

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L188I	TCGA-61-1725	OV	TCGA	SLDNGE	DEG_Kelch_Keap1_1	0.6667
p.H183N	TCGA-BS-A0UV	UCEC	TCGA	SLDNGE	DEG_Kelch_Keap1_1	0.0833
p.D196G	TCGA-E7-A7DV	BLCA	TCGA	SLDNGE	DEG_Kelch_Keap1_1	0.7198
p.V198G	DO48396	BLCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.3056
p.V198G	DO48363	BLCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.3056
p.H203R	DO9346	COAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.1667
p.R190W	DO8730	COAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO222798	COCA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO13863	GBM	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO14393	HNSC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO36881	READ	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO43186	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO42400	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.R190W	DO41361	UCEC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.Q188K	DO228969	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.6667
p.R196K	DO228974	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.7237
p.L197M	DO229031	LICA	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.711
p.S204T	DO45527	LUSC	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.1389
p.R190Q	DO48016	STAD	ICGC	SLDNGE	DEG_Kelch_Keap1_1	0.2778
p.L186F	SIDM00025	Head and Neck Carcinoma	GDSC	SLDNGE	DEG_Kelch_Keap1_1	0.1667
p.L186F	UDSCC2	upper_aerodigestive_tract	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	0.1667
p.L184F	ACH-002391	Head and Neck Cancer	CCLE	SLDNGE	DEG_Kelch_Keap1_1	0.1111
p.L184F	UDSCC2	upper_aerodigestive_tract	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	0.1111
p.R183C	COLO-205	large_intestine	COSMIC	SLDNGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UNZ2	NSFL1 cofactor p47	DEG_Kelch_Keap1_1	192:197	SLDNGE	KEAP1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons