DegronMD

Uniprot ID: Q6IPM2

Source protein: IQ domain-containing protein E

Source gene: IQCE

Class: DEG_ODPH_VHL_1

Location: 684:695

E3 ligase: VHL

DEGRON score: 0.6195

ASA_SCORE: 85.1333

COIL: 0.839

CONS_SCORE: 0.6766

DSS_SCORE: 0.7136

HELIX: 0.0273

FCONS_SCORE: 0.9262

RIG_SCORE: 0.737

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K691N	TCGA-CA-6717	COAD	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.5806
p.K691N	TCGA-D1-A16X	UCEC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.5806
p.K691N	TCGA-E6-A1LX	UCEC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.5806
p.V674I	TCGA-QA-A7B7	LIHC	TCGA	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.0556
p.D681N	SIDM02055	Colorectal Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.25
p.Q675H	SIDM00697	Small Cell Lung Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.0833
p.Q675H	NCI-H1436	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.0833
p.R685W	SIDM01040	Ovarian Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	SIDM00555	Glioblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	SIDM00273	Glioblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	KS-1	central_nervous_system	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	GI-1	central_nervous_system	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	FU-OV-1	ovary	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.R685W	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.8634
p.V694M	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.7208
p.V694M	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.7208
p.I682T	SIDM00556	Neuroblastoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.2778
p.I682T	ACH-000227	Neuroblastoma	CCLE	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.2778
p.I682T	KP-N-YN	autonomic_ganglia	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.2778
p.G692R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.7568
p.G692R	HCC-15	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.7568
p.S688L	SIDM01619	Endometrial Carcinoma	GDSC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.7667
p.G676R	HCC-15	lung	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.1111
p.V678M	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	IAPSLPTKNFPV	DEG_ODPH_VHL_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPSLPTKNFPV

Degron related mutations and impact score

Drug responses associated with IQCE mutations

All proteins holding degron of IAPSLPTKNFPV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IPM2	IQ domain-containing protein E	DEG_ODPH_VHL_1	684:695	IAPSLPTKNFPV	VHL	0.6195	More...