DegronMD

Uniprot ID: P54132

Source protein: Bloom syndrome protein

Source gene: BLM

Class: DEG_SPOP_SBC_1

Location: 355:359

E3 ligase: SPOP

DEGRON score: 0.986

ASA_SCORE: 86.02

COIL: 0.82

CONS_SCORE: 0.2148

DSS_SCORE: 0.5501

HELIX: 0.1602

FCONS_SCORE: 0.9908

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M350I	TCGA-AP-A059	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	0.1944
p.M350I	DO41361	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	0.1944
p.M348I	TCGA-UC-A7PG	CESC	TCGA	PETST	DEG_SPOP_SBC_1	0.1389
p.M348I	DO51615	CESC	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.M348I	DO229005	COCA	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.M348I	SIDM00588	Oral Cavity Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	0.1389
p.M348I	SIDM01447	Glioblastoma	GDSC	PETST	DEG_SPOP_SBC_1	0.1389
p.M348I	HSC-4	upper_aerodigestive_tract	COSMIC	PETST	DEG_SPOP_SBC_1	0.1389
p.M348V	TCGA-Y8-A894	KIRP	TCGA	PETST	DEG_SPOP_SBC_1	0.1389
p.M348V	DO49798	KIRP	ICGC	PETST	DEG_SPOP_SBC_1	0.1389
p.E346K	DO223035	ESCA	ICGC	PETST	DEG_SPOP_SBC_1	0.0833
p.Q365L	DO228217	LICA	ICGC	PETST	DEG_SPOP_SBC_1	0.1667
p.I366T	SIDM01113	Other Sarcomas	GDSC	PETST	DEG_SPOP_SBC_1	0.1389
p.I366T	SK-UT-1	soft_tissue	COSMIC	PETST	DEG_SPOP_SBC_1	0.1389
p.K347N	SIDM00118	Colorectal Carcinoma	GDSC	PETST	DEG_SPOP_SBC_1	0.2222
p.K347N	ACH-001081	Colon/Colorectal Cancer	CCLE	PETST	DEG_SPOP_SBC_1	0.2222
p.K347N	HCC2998	large_intestine	COSMIC	PETST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	355:359	PETST	SPOP	0.986	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	266:270	PETST	SPOP	0.5927	More...
Q5BJH2	Transmembrane protein 128	DEG_SPOP_SBC_1	32:36	PETST	SPOP	0.8321	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8176:8180	PETST	SPOP	0.5974	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1235:1239	PETST	SPOP	0.6169	More...
Q9Y572	Receptor-interacting serine/threonine-protein kinase 3	DEG_SPOP_SBC_1	399:403	PETST	SPOP	0.9132	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons