DegronMD - Q5BJH2(TMEM128)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L24R	TCGA-DD-A3A8	LIHC	TCGA	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1111
p.V37F	TCGA-DD-AACT	LIHC	TCGA	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.3056
p.H27Y	TCGA-EE-A29R	SKCM	TCGA	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.1944
p.A34T	TCGA-EO-A3AZ	UCEC	TCGA	PETST	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.7139
p.K43E	DO223732	CESC	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation substituting flanking lysine	0.25
p.V38F	DO234152	ESAD	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.2778
p.D29E	DO229027	LICA	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25
p.K43T	DO47769	STAD	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation substituting flanking lysine	0.25
p.A30S	DO229272	THCA	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.2778
p.K40Q	DO43306	UCEC	ICGC	PETST	DEG_SPOP_SBC_1	32:36	Mutation substituting flanking lysine	0.3333
p.P32L	ACH-001528	Thyroid Cancer	CCLE	PETST	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.7582

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons