DegronMD

Uniprot ID: P56975

Source protein: Pro-neuregulin-3, membrane-bound isoform

Source gene: NRG3

Class: LIG_APCC_ABBA_1

Location: 244:249

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9998

ASA_SCORE: 80.3167

COIL: 0.8267

CONS_SCORE: 0.3711

DSS_SCORE: 0.4566

HELIX: 0.0678

FCONS_SCORE: 0.9863

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S238P	TCGA-MH-A55W	KIRP	TCGA	LSPFQD	LIG_APCC_ABBA_1	0.1667
p.S238P	DO48516	KIRP	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.1667
p.D237N	DO222884	COCA	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.1389
p.W242S	DO233730	GACA	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.2778
p.G259V	DO20786	KIRP	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.P234S	DO228589	LICA	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.P237S	DO231797	LINC	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.1389
p.H248Y	DO25153	LUAD	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.7229
p.C255S	DO231155	LUSC	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.6111
p.S259F	DO222702	MELA	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.S245P	DO232761	PBCA	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.5641
p.G259R	DO51301	SKCM	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.P237T	DO219464	SKCM	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.1389
p.P258T	DO41584	UCEC	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.0833
p.S245Y	DO41133	UCEC	ICGC	LSPFQD	LIG_APCC_ABBA_1	0.6009
p.V259F	SNG-M	endometrium	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.D258E	NCI-H1581	lung	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.0833
p.R241K	K2	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.25
p.P259H	HMV-II	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.P240S	MRK-nu-1	breast	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.2222
p.A244T	OC-314	ovary	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.7139
p.P234H	HMV-II	skin	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.V259I	OCI-LY-19	haematopoietic_and_lymphoid_tissue	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.0556
p.S241I	SNU-1040	large_intestine	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.25
p.P255L	KYSE-510	oesophagus	COSMIC	LSPFQD	LIG_APCC_ABBA_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56975	Pro-neuregulin-3, membrane-bound isoform	LIG_APCC_ABBA_1	244:249	LSPFQD	APC,CDC20,FZR1	0.9998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons