DegronMD

Uniprot ID: P56975

Source protein: Pro-neuregulin-3, membrane-bound isoform

Source gene: NRG3

Class: DEG_APCC_DBOX_1

Location: 498:506

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8092

ASA_SCORE: 86.7889

COIL: 0.9016

CONS_SCORE: 0.5419

DSS_SCORE: 0.6311

HELIX: 0.0383

FCONS_SCORE: 0.8667

RIG_SCORE: 0.6269

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P508S	TCGA-05-4398	LUAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.2778
p.G503V	TCGA-05-5425	LUAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.6421
p.R493M	TCGA-A5-A0GH	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.1944
p.S500R	TCGA-A5-A1OF	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.6316
p.E514K	TCGA-AG-3878	READ	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E514K	TCGA-BT-A20T	BLCA	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E514K	TCGA-VQ-A8PH	STAD	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E514K	ACH-002508	Skin Cancer	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E515D	TCGA-AP-A1E0	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.0833
p.P496L	TCGA-B5-A3FA	UCEC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.2778
p.P496L	ACH-001736	Leukemia	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	0.2778
p.L502V	TCGA-C8-A1HM	BRCA	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.6765
p.R499Q	TCGA-IR-A3LA	CESC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.7329
p.G503A	TCGA-NC-A5HM	LUSC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.6429
p.A509P	TCGA-T2-A6WZ	HNSC	TCGA	PRSRLGGIV	DEG_APCC_DBOX_1	0.25
p.D494Y	DO8264	COAD	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.2222
p.R493K	DO15623	HNSC	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.1944
p.E490K	DO222647	MELA	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E490K	DO38051	SKCM	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.E490K	DO51298	SKCM	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.S495Y	DO47769	STAD	ICGC	PRSRLGGIV	DEG_APCC_DBOX_1	0.25
p.G504E	SIDM01175	Other Sarcomas	GDSC	PRSRLGGIV	DEG_APCC_DBOX_1	0.6087
p.G504E	ACH-002309	Sarcoma	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	0.6087
p.G504E	SW684	soft_tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.6087
p.G507V	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	PRSRLGGIV	DEG_APCC_DBOX_1	0.3056
p.G507V	ACH-000718	Lung Cancer	CCLE	PRSRLGGIV	DEG_APCC_DBOX_1	0.3056
p.G507V	NCI-H2291	lung	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.3056
p.N489D	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.0833
p.N490D	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.1111
p.R508Q	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.2778
p.N516D	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PRSRLGGIV	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSRLGGIV

Degron related mutations and impact score

Drug responses associated with NRG3 mutations

All proteins holding degron of PRSRLGGIV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_APCC_DBOX_1	498:506	PRSRLGGIV	APC,CDC20,FZR1	0.8092	More...