DegronMD

Uniprot ID: P10275

Source protein: Androgen receptor

Source gene: AR

Class: DEG_SPOP_SBC_1

Location: 646:650

E3 ligase: SPOP

DEGRON score: 0.8976

ASA_SCORE: 90.34

COIL: 0.9602

CONS_SCORE: 0.3925

DSS_SCORE: 0.6495

HELIX: 0.0242

FCONS_SCORE: 0.7689

RIG_SCORE: 0.6113

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E645K	TCGA-FW-A3R5	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E645K	DO37406	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.F644L	CAL-62	thyroid	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.2778
p.Q641H	SIDM00193	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.Q641H	ACH-000991	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	0.1944
p.Q641H	SNU-81	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.G636C	TCGA-MN-A4N4	LUAD	TCGA	ASSTT	DEG_SPOP_SBC_1	0.0556
p.G636C	DO26250	LUAD	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0556

Showing 1 to 8 of 8 entries

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Drug responses associated with AR mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	7.6848
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	AZD3514	20.33
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	71.0099
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	13.0344
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	AZD3514	4.8095
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	114.6281
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	6.1747
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	AZD3514	21.3658
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	70.4477
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	16.1827
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	AZD3514	32.1642
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	148.5768
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	4.5387
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	AZD3514	23.9848
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	66.6243
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	9.1072
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	AZD3514	34.4153
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	64.7057
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	11.3736
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	AZD3514	6.1296
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	24.1556
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	13.0587
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	AZD3514	12.8729
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	70.3036
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	AZD3514	85.3921

Showing 1 to 25 of 141 entries

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All proteins holding degron of ASSTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C9		DEG_SPOP_SBC_1	498:502	ASSTT	SPOP	0.9902	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	646:650	ASSTT	SPOP	0.8976	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	280:284	ASSTT	SPOP	0.98	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3480:3484	ASSTT	SPOP	0.8983	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	578:582	ASSTT	SPOP	0.9349	More...
P02724	Glycophorin-A	DEG_SPOP_SBC_1	19:23	ASSTT	SPOP	0.916	More...
A6NI86	Golgin subfamily A member 6-like protein 10	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.832	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1194:1198	ASSTT	SPOP	0.9483	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	1181:1185	ASSTT	SPOP	0.7757	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	83:87	ASSTT	SPOP	0.9996	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1624:1628	ASSTT	SPOP	0.9708	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1873:1877	ASSTT	SPOP	0.9842	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3181:3185	ASSTT	SPOP	0.9778	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3430:3434	ASSTT	SPOP	0.9869	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4264:4268	ASSTT	SPOP	0.9753	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4513:4517	ASSTT	SPOP	0.9852	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4706:4710	ASSTT	SPOP	0.5037	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4079:4083	ASSTT	SPOP	0.9127	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	154:158	ASSTT	SPOP	0.9742	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1605:1609	ASSTT	SPOP	0.5454	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1617:1621	ASSTT	SPOP	0.9919	More...
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_SPOP_SBC_1	662:666	ASSTT	SPOP	0.9983	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2640:2644	ASSTT	SPOP	0.9344	More...
P49683	Prolactin-releasing peptide receptor	DEG_SPOP_SBC_1	2:6	ASSTT	SPOP	0.9979	More...

Showing 1 to 25 of 34 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTT

Degron related mutations and impact score

Drug responses associated with AR mutations

All proteins holding degron of ASSTT