DegronMD

Uniprot ID: P10275

Source protein: Androgen receptor

Source gene: AR

Class: DEG_SPOP_SBC_1

Location: 646:650

E3 ligase: SPOP

DEGRON score: 0.8976

ASA_SCORE: 90.34

COIL: 0.9602

CONS_SCORE: 0.3925

DSS_SCORE: 0.6495

HELIX: 0.0242

FCONS_SCORE: 0.7689

RIG_SCORE: 0.6113

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E645K	TCGA-FW-A3R5	SKCM	TCGA	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E645K	DO37406	SKCM	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.G636C	TCGA-MN-A4N4	LUAD	TCGA	ASSTT	DEG_SPOP_SBC_1	0.0556
p.G636C	DO26250	LUAD	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.Q641H	SIDM00193	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.Q641H	ACH-000991	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	0.1944
p.Q641H	SNU-81	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.F644L	CAL-62	thyroid	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.2778

Drug responses associated with AR mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00687	STAD\|stomach	p.E666K (No)	GDSC	AZD3514	107.2435
SIDM00720	MESO\|mesothelioma	p.T559S (No)	GDSC	Bicalutamide	23.3521
SIDM00720	MESO\|mesothelioma	p.T559S (No)	GDSC	AZD3514	24.9412
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.T282S (No)	GDSC	AZD3514	21.4569
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.T282S (No)	GDSC	Bicalutamide	90.3701
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	Bicalutamide	14.3028
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	AZD3514	8.3404
SIDM00931	THCA\|thyroid	p.F827L (No)	GDSC	Bicalutamide	87.3317
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	Bicalutamide	15.121
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	AZD3514	26.5149
SIDM00213	THCA\|thyroid	p.A270T (No)	GDSC	Bicalutamide	69.4917
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	Bicalutamide	9.9598
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	AZD3514	22.1595
SIDM00499	PRAD\|prostate	p.H875Y (No)	GDSC	Bicalutamide	155.6449
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	Bicalutamide	10.3299
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	AZD3514	6.6898
SIDM00683	PRAD\|prostate	p.K593E (No)	GDSC	Bicalutamide	13.4612
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	Bicalutamide	10.3299
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	AZD3514	6.6898
SIDM00683	PRAD\|prostate	p.T878A (No)	GDSC	Bicalutamide	13.4612
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	6.1747
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	AZD3514	21.3658
SIDM00272	BRCA\|breast	p.Q868H (No)	GDSC	Bicalutamide	70.4477
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	Bicalutamide	12.4442
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	AZD3514	8.355
SIDM00453	PAAD\|pancreas	p.L548F (No)	GDSC	Bicalutamide	32.6021
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	16.1827
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	AZD3514	32.1642
SIDM00881	BRCA\|breast	p.A680G (No)	GDSC	Bicalutamide	148.5768
SIDM00393	STAD\|stomach	p.A385S (No)	GDSC	AZD3514	31.3409
SIDM00393	STAD\|stomach	p.A385S (No)	GDSC	Bicalutamide	59.4103
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	7.6848
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	AZD3514	20.33
SIDM00999	BLCA\|bladder	p.Q803fs*6 (No)	GDSC	Bicalutamide	71.0099
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	Bicalutamide	16.9193
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	AZD3514	20.9852
SIDM00202	UNCLASSIFIED\|ewings_sarcoma	p.P392S (No)	GDSC	Bicalutamide	70.8216
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	13.0587
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	AZD3514	12.8729
SIDM01090	COREAD\|large_intestine	p.T306I (No)	GDSC	Bicalutamide	70.3036
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	Bicalutamide	19.1622
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	AZD3514	91.5292
SIDM00239	KIRC\|kidney	p.Y514H (No)	GDSC	Bicalutamide	227.6454
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	Bicalutamide	42.2008
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	AZD3514	37.1772
SIDM00484	THCA\|thyroid	p.P392S (No)	GDSC	Bicalutamide	207.8642
SIDM00577	NB\|neuroblastoma	p.D354E (No)	GDSC	Bicalutamide	16.2078
SIDM00577	NB\|neuroblastoma	p.D354E (No)	GDSC	AZD3514	50.4555
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	Bicalutamide	16.6193
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	AZD3514	28.6147
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.V716L (No)	GDSC	Bicalutamide	39.8131
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	9.1072
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	AZD3514	34.4153
SIDM00846	CESC\|cervix	p.Q70_Q80delQQQQQQQQQQQ (No)	GDSC	Bicalutamide	64.7057
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.E32K (No)	GDSC	Bicalutamide	110.8292
SIDM00217	COREAD\|large_intestine	p.R775H (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.R775H (No)	GDSC	Bicalutamide	110.8292
SIDM00217	COREAD\|large_intestine	p.T851A (No)	GDSC	AZD3514	85.3921
SIDM00217	COREAD\|large_intestine	p.T851A (No)	GDSC	Bicalutamide	110.8292
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	Bicalutamide	16.1961
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	AZD3514	25.1651
SIDM00140	SKCM\|melanoma	p.P555L (No)	GDSC	Bicalutamide	154.7129
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	11.3736
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	AZD3514	6.1296
SIDM00889	CESC\|cervix	p.G624W (No)	GDSC	Bicalutamide	24.1556
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	Bicalutamide	14.5368
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	AZD3514	27.7026
SIDM01128	SCLC\|lung_small_cell_carcinoma	p.A588S (No)	GDSC	Bicalutamide	127.1966
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	Bicalutamide	14.4072
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	AZD3514	31.4925
SIDM00567	MB\|medulloblastoma	p.Y514H (No)	GDSC	Bicalutamide	77.6133
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	Bicalutamide	7.0416
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	AZD3514	73.7135
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V912I (No)	GDSC	Bicalutamide	81.8414
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	Bicalutamide	25.7032
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	AZD3514	58.9207
SIDM00359	COREAD\|large_intestine	p.G334R (No)	GDSC	Bicalutamide	176.7793
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	Bicalutamide	8.853
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	AZD3514	45.7693
SIDM00125	KIRC\|kidney	p.S598G (No)	GDSC	Bicalutamide	74.3852
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	Bicalutamide	6.6391
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	AZD3514	71.9949
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.Q592H (No)	GDSC	Bicalutamide	83.782
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	Bicalutamide	13.3911
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	AZD3514	81.503
SIDM00534	COREAD\|large_intestine	p.A871V (No)	GDSC	Bicalutamide	31.9378
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	Bicalutamide	8.2473
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	AZD3514	29.3747
SIDM00861	UNCLASSIFIED\|ovary	p.E707K (No)	GDSC	Bicalutamide	93.5657
SIDM00850	STAD\|stomach	p.E773V (No)	GDSC	Bicalutamide	10.1759
SIDM00850	STAD\|stomach	p.E773V (No)	GDSC	AZD3514	28.3881
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	Bicalutamide	24.6121
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	AZD3514	58.7699
SIDM00545	SKCM\|melanoma	p.E523D (No)	GDSC	Bicalutamide	179.0194
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	Bicalutamide	14.4538
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	AZD3514	45.3914
SIDM00142	UCEC\|endometrium	p.G525fs*37 (No)	GDSC	Bicalutamide	152.1623
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	Bicalutamide	13.9369
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	AZD3514	11.6293
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.S244L (No)	GDSC	Bicalutamide	88.0343
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	Bicalutamide	8.2531
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	AZD3514	14.288
SIDM00616	LIHC\|liver	p.K610R (No)	GDSC	Bicalutamide	61.8995
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	Bicalutamide	24.2256
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	AZD3514	85.7849
SIDM00328	ESCA\|oesophagus	p.D733N (No)	GDSC	Bicalutamide	182.5489
SIDM00895	DLBC\|B_cell_lymphoma	p.E323K (No)	GDSC	Bicalutamide	6.7861
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	13.0344
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	AZD3514	4.8095
SIDM00983	BLCA\|bladder	p.V716M (No)	GDSC	Bicalutamide	114.6281
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	Bicalutamide	44.3943
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	AZD3514	129.1198
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.L249M (No)	GDSC	Bicalutamide	196.849
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	Bicalutamide	15.8164
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	AZD3514	16.2666
SIDM00133	LUAD\|lung_NSCLC_adenocarcinoma	p.G329C (No)	GDSC	Bicalutamide	110.66
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	Bicalutamide	9.8937
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	AZD3514	34.4877
SIDM00537	COREAD\|large_intestine	p.Y552H (No)	GDSC	Bicalutamide	89.9366
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	Bicalutamide	16.6168
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	AZD3514	15.0872
SIDM01040	OV\|ovary	p.C602Y (No)	GDSC	Bicalutamide	192.3216
SIDM00054	PAAD\|pancreas	p.D354E (No)	GDSC	Bicalutamide	12.4863
SIDM00054	PAAD\|pancreas	p.D354E (No)	GDSC	Bicalutamide	122.38
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	4.5387
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	AZD3514	23.9848
SIDM01001	BRCA\|breast	p.R386C (No)	GDSC	Bicalutamide	66.6243
SIDM00193	COREAD\|large_intestine	p.Q641H (Yes)	GDSC	AZD3514	129.7398
SIDM00193	COREAD\|large_intestine	p.Q641H (Yes)	GDSC	Bicalutamide	103.79
SIDM00193	COREAD\|large_intestine	p.P818S (No)	GDSC	AZD3514	129.7398
SIDM00193	COREAD\|large_intestine	p.P818S (No)	GDSC	Bicalutamide	103.79
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	Bicalutamide	13.0412
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	AZD3514	61.1386
SIDM00118	COREAD\|large_intestine	p.R711G (No)	GDSC	Bicalutamide	82.5525
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	Bicalutamide	13.0412
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	AZD3514	61.1386
SIDM00118	COREAD\|large_intestine	p.E830* (No)	GDSC	Bicalutamide	82.5525
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	Bicalutamide	20.5506
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	AZD3514	50.1711
SIDM00697	SCLC\|lung_small_cell_carcinoma	p.A810P (No)	GDSC	Bicalutamide	112.6285

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43290	U4/U6.U5 tri-snRNP-associated protein 1	DEG_SPOP_SBC_1	622:626	ASSTT	SPOP	0.9972	More...
P02724	Glycophorin-A	DEG_SPOP_SBC_1	19:23	ASSTT	SPOP	0.916	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	646:650	ASSTT	SPOP	0.8976	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1617:1621	ASSTT	SPOP	0.9919	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	1181:1185	ASSTT	SPOP	0.7757	More...
P49683	Prolactin-releasing peptide receptor	DEG_SPOP_SBC_1	2:6	ASSTT	SPOP	0.9979	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1095:1099	ASSTT	SPOP	0.9514	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2640:2644	ASSTT	SPOP	0.9344	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	578:582	ASSTT	SPOP	0.9349	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4079:4083	ASSTT	SPOP	0.9127	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	731:735	ASSTT	SPOP	0.8162	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3480:3484	ASSTT	SPOP	0.8983	More...
Q8IX21	SMC5-SMC6 complex localization factor protein 2	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9928	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1244:1248	ASSTT	SPOP	0.9839	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	152:156	ASSTT	SPOP	0.7948	More...
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_SPOP_SBC_1	662:666	ASSTT	SPOP	0.9983	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1194:1198	ASSTT	SPOP	0.9483	More...
Q9C0C9		DEG_SPOP_SBC_1	498:502	ASSTT	SPOP	0.9902	More...
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SPOP_SBC_1	250:254	ASSTT	SPOP	0.9353	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1624:1628	ASSTT	SPOP	0.9708	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1873:1877	ASSTT	SPOP	0.9842	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3181:3185	ASSTT	SPOP	0.9778	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3430:3434	ASSTT	SPOP	0.9869	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4264:4268	ASSTT	SPOP	0.9753	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4513:4517	ASSTT	SPOP	0.9852	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4706:4710	ASSTT	SPOP	0.5037	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	83:87	ASSTT	SPOP	0.9996	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	154:158	ASSTT	SPOP	0.9742	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1605:1609	ASSTT	SPOP	0.5454	More...
A6NEY3	Putative golgin subfamily A member 6-like protein 3	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.7368	More...
A6NI86	Golgin subfamily A member 6-like protein 10	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.832	More...
H0YKK7	Putative golgin subfamily A member 6-like protein 19	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.713	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	280:284	ASSTT	SPOP	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTT

Degron related mutations and impact score

Drug responses associated with AR mutations

All proteins holding degron of ASSTT