DegronMD - Q9C0C9(UBE2O)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1226T	TCGA-63-A5MM	LUSC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7139
p.A1226T	TCGA-AJ-A3EL	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7139
p.A1226T	DO219153	LUSC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7139
p.A1226T	DO41542	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7139
p.R1237W	TCGA-B5-A11E	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.1667
p.R1237W	DO41644	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.1667
p.D1214E	TCGA-CK-4948	COAD	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.0833
p.D1214E	DO10598	COAD	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.0833
p.R1237L	TCGA-CN-6010	HNSC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.1667
p.R1237L	DO14766	HNSC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.1667
p.T510M	TCGA-DU-6392	LGG	TCGA	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.T510M	DO22237	LGG	ICGC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.1111
p.S506R	TCGA-EO-A3B0	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.S506R	DO219773	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.2222
p.S1231N	TCGA-EO-A3KX	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7069
p.S1231N	DO219774	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7069
p.D1214N	TCGA-FD-A6TH	BLCA	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.0833
p.D1214N	DO49763	BLCA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.0833
p.A1223E	TCGA-G3-A7M9	LIHC	TCGA	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.659
p.A1223E	DO49694	LIHC	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.659
p.P1229T	DO222973	BTCA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.5919
p.P1229S	DO52456	COCA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.5641
p.A498S	DO233634	GACA	ICGC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation altering degron motif	0.7588
p.R1237Q	DO233804	GACA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.1667
p.Q505K	DO229036	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.25
p.D1225E	DO229038	LICA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.5647
p.S1227L	DO222843	MELA	ICGC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation altering degron motif	0.7667
p.R512L	SIDM00655	Other Solid Cancers	GDSC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.R512L	ACH-001578	Embryonal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.R512L	NCCIT	testis	COSMIC	ASSTT	DEG_SPOP_SBC_1	498:502	Mutation rewiring degron network	0.0556
p.T1222N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.3056
p.T1222N	ACH-000492	Leukemia	CCLE	APDASVPPS	DEG_SIAH_1	1223:1231	Mutation rewiring degron network	0.3056

Kaplan plot for UBE2O in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBE2O

UniProt ID: Q9C0C9

Entrez ID: 63893

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for UBE2O in