DegronMD

Uniprot ID: Q9C0C9

Source protein:

Source gene: UBE2O

Class: DEG_SIAH_1

Location: 1223:1231

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9942

ASA_SCORE: 86.2889

COIL: 0.9376

CONS_SCORE: 0.2776

DSS_SCORE: 0.7316

HELIX: 0.036

FCONS_SCORE: 1.0177

RIG_SCORE: 0.6131

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1226T	TCGA-63-A5MM	LUSC	TCGA	APDASVPPS	DEG_SIAH_1	0.7139
p.A1226T	TCGA-AJ-A3EL	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	0.7139
p.A1226T	DO219153	LUSC	ICGC	APDASVPPS	DEG_SIAH_1	0.7139
p.A1226T	DO41542	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	0.7139
p.R1237W	TCGA-B5-A11E	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	0.1667
p.R1237W	DO41644	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	0.1667
p.D1214E	TCGA-CK-4948	COAD	TCGA	APDASVPPS	DEG_SIAH_1	0.0833
p.D1214E	DO10598	COAD	ICGC	APDASVPPS	DEG_SIAH_1	0.0833
p.R1237L	TCGA-CN-6010	HNSC	TCGA	APDASVPPS	DEG_SIAH_1	0.1667
p.R1237L	DO14766	HNSC	ICGC	APDASVPPS	DEG_SIAH_1	0.1667
p.S1231N	TCGA-EO-A3KX	UCEC	TCGA	APDASVPPS	DEG_SIAH_1	0.7069
p.S1231N	DO219774	UCEC	ICGC	APDASVPPS	DEG_SIAH_1	0.7069
p.D1214N	TCGA-FD-A6TH	BLCA	TCGA	APDASVPPS	DEG_SIAH_1	0.0833
p.D1214N	DO49763	BLCA	ICGC	APDASVPPS	DEG_SIAH_1	0.0833
p.A1223E	TCGA-G3-A7M9	LIHC	TCGA	APDASVPPS	DEG_SIAH_1	0.659
p.A1223E	DO49694	LIHC	ICGC	APDASVPPS	DEG_SIAH_1	0.659
p.P1229T	DO222973	BTCA	ICGC	APDASVPPS	DEG_SIAH_1	0.5919
p.P1229S	DO52456	COCA	ICGC	APDASVPPS	DEG_SIAH_1	0.5641
p.R1237Q	DO233804	GACA	ICGC	APDASVPPS	DEG_SIAH_1	0.1667
p.D1225E	DO229038	LICA	ICGC	APDASVPPS	DEG_SIAH_1	0.5647
p.S1227L	DO222843	MELA	ICGC	APDASVPPS	DEG_SIAH_1	0.7667
p.T1222N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	APDASVPPS	DEG_SIAH_1	0.3056
p.T1222N	ACH-000492	Leukemia	CCLE	APDASVPPS	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C9		DEG_SIAH_1	1223:1231	APDASVPPS	SIAH1,SIAH2,SIAH3	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons