DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ASSTT
Uniprot ID:
H0YKK7
Source protein:
Putative golgin subfamily A member 6-like protein 19
Source gene:
GOLGA6L19
Class:
DEG_SPOP_SBC_1
Location:
79:83
E3 ligase:
SPOP
DEGRON score:
0.713
ASA_SCORE:
74.58
COIL:
0.7358
CONS_SCORE:
0.8052
DSS_SCORE:
0.4808
HELIX:
0.2392
FCONS_SCORE:
0.8835
RIG_SCORE:
0.7213
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with GOLGA6L19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ASSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O43290
U4/U6.U5 tri-snRNP-associated protein 1
DEG_SPOP_SBC_1
622:626
ASSTT
SPOP
0.9972
More...
P02724
Glycophorin-A
DEG_SPOP_SBC_1
19:23
ASSTT
SPOP
0.916
More...
P10275
Androgen receptor
DEG_SPOP_SBC_1
646:650
ASSTT
SPOP
0.8976
More...
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1617:1621
ASSTT
SPOP
0.9919
More...
P41229
Lysine-specific demethylase 5C
DEG_SPOP_SBC_1
1181:1185
ASSTT
SPOP
0.7757
More...
P49683
Prolactin-releasing peptide receptor
DEG_SPOP_SBC_1
2:6
ASSTT
SPOP
0.9979
More...
Q07889
Son of sevenless homolog 1
DEG_SPOP_SBC_1
1095:1099
ASSTT
SPOP
0.9514
More...
Q15751
Probable E3 ubiquitin-protein ligase HERC1
DEG_SPOP_SBC_1
2640:2644
ASSTT
SPOP
0.9344
More...
Q5SYB0
FERM and PDZ domain-containing protein 1
DEG_SPOP_SBC_1
578:582
ASSTT
SPOP
0.9349
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
4079:4083
ASSTT
SPOP
0.9127
More...
Q6ZSB9
Zinc finger and BTB domain-containing protein 49
DEG_SPOP_SBC_1
731:735
ASSTT
SPOP
0.8162
More...
Q7Z6Z7
E3 ubiquitin-protein ligase HUWE1
DEG_SPOP_SBC_1
3480:3484
ASSTT
SPOP
0.8983
More...
Q8IX21
SMC5-SMC6 complex localization factor protein 2
DEG_SPOP_SBC_1
462:466
ASSTT
SPOP
0.9928
More...
Q8NI27
THO complex subunit 2
DEG_SPOP_SBC_1
1244:1248
ASSTT
SPOP
0.9839
More...
Q8TBK6
Zinc finger CCHC domain-containing protein 10
DEG_SPOP_SBC_1
152:156
ASSTT
SPOP
0.7948
More...
Q92841
Probable ATP-dependent RNA helicase DDX17
DEG_SPOP_SBC_1
662:666
ASSTT
SPOP
0.9983
More...
Q9C091
GREB1-like protein
DEG_SPOP_SBC_1
1194:1198
ASSTT
SPOP
0.9483
More...
Q9C0C9
DEG_SPOP_SBC_1
498:502
ASSTT
SPOP
0.9902
More...
Q9UGI6
Small conductance calcium-activated potassium channel protein 3
DEG_SPOP_SBC_1
250:254
ASSTT
SPOP
0.9353
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
462:466
ASSTT
SPOP
0.9801
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1624:1628
ASSTT
SPOP
0.9708
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
1873:1877
ASSTT
SPOP
0.9842
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3181:3185
ASSTT
SPOP
0.9778
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
3430:3434
ASSTT
SPOP
0.9869
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4264:4268
ASSTT
SPOP
0.9753
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4513:4517
ASSTT
SPOP
0.9852
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
4706:4710
ASSTT
SPOP
0.5037
More...
Q9UNF1
Melanoma-associated antigen D2
DEG_SPOP_SBC_1
83:87
ASSTT
SPOP
0.9996
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
154:158
ASSTT
SPOP
0.9742
More...
E2RYF6
Mucin-22
DEG_SPOP_SBC_1
1605:1609
ASSTT
SPOP
0.5454
More...
A6NEY3
Putative golgin subfamily A member 6-like protein 3
DEG_SPOP_SBC_1
79:83
ASSTT
SPOP
0.7368
More...
A6NI86
Golgin subfamily A member 6-like protein 10
DEG_SPOP_SBC_1
79:83
ASSTT
SPOP
0.832
More...
H0YKK7
Putative golgin subfamily A member 6-like protein 19
DEG_SPOP_SBC_1
79:83
ASSTT
SPOP
0.713
More...
Q9NQR7
Coiled-coil domain-containing protein 177
DEG_SPOP_SBC_1
280:284
ASSTT
SPOP
0.98
More...