DegronMD - P02724(GYPA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A26V	TCGA-G4-6588	COAD	TCGA	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.25
p.A26V	DO10140	COAD	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.25
p.A33T	DO7166	CLLE	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0556
p.L20S	DO222703	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO222888	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229005	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO228706	EOPC	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229031	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229006	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO45299	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO45099	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO23509	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO52372	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO52341	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229103	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229232	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.L20S	DO229095	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7667
p.E24D	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.E24D	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.E24D	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.E13A	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.E13A	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.E13A	DO229016	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.E13A	DO229003	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.E13A	DO229005	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1667
p.E24G	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.E24G	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.E24G	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.T14K	DO26433	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1944
p.L9S	DO219878	SKCA	ICGC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0556
p.L11F	SIDM02018	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.T23N	SIDM00458	Acute Myeloid Leukemia	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7055
p.T23N	ACH-000751	Leukemia	CCLE	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7055
p.L11S	SIDM01117	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.L11S	SIDM00656	Burkitt's Lymphoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.L11S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.L11S	SIDM00673	Breast Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.L11S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.L11S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.S32C	ACH-000445	Brain Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0833
p.G20V	NCI-H2291	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7532
p.T10R	ABC-1	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0833
p.T10R	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0833
p.H27N	COLO-741	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.2222
p.H27N	U031	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.2222
p.L30I	NCI-H841	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1389
p.G33V	NCI-H2291	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0556
p.M22I	SK-GT-4	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7618

Kaplan plot for GYPA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GYPA

UniProt ID: P02724

Entrez ID: 2993

Protein name: Glycophorin-A (MN sialoglycoprotein) (PAS-2) (Sialoglycoprotein alpha) (CD antigen CD235a)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GYPA in