DegronMD

Uniprot ID: P02724

Source protein: Glycophorin-A

Source gene: GYPA

Class: DEG_SPOP_SBC_1

Location: 19:23

E3 ligase: SPOP

DEGRON score: 0.916

ASA_SCORE: 79.24

COIL: 0.8096

CONS_SCORE: 0.3264

DSS_SCORE: 0.1553

HELIX: 0.0974

FCONS_SCORE: 0.76

RIG_SCORE: 0.7236

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A26V	TCGA-G4-6588	COAD	TCGA	ASSTT	DEG_SPOP_SBC_1	0.25
p.A26V	DO10140	COAD	ICGC	ASSTT	DEG_SPOP_SBC_1	0.25
p.A33T	DO7166	CLLE	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.L20S	DO222703	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO222888	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229005	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO228706	EOPC	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229031	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229006	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO45299	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO45099	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO23509	LIRI	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO52372	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO52341	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229103	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229232	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.L20S	DO229095	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.7667
p.E24D	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E24D	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E24D	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E13A	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.E13A	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.E13A	DO229016	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.E13A	DO229003	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.E13A	DO229005	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.E24G	DO229010	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E24G	DO229013	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.E24G	DO228947	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.3056
p.T14K	DO26433	LUSC	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.L9S	DO219878	SKCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.L11F	SIDM02018	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.T23N	SIDM00458	Acute Myeloid Leukemia	GDSC	ASSTT	DEG_SPOP_SBC_1	0.7055
p.T23N	ACH-000751	Leukemia	CCLE	ASSTT	DEG_SPOP_SBC_1	0.7055
p.L11S	SIDM01117	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.L11S	SIDM00656	Burkitt's Lymphoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.L11S	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.L11S	SIDM00673	Breast Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.L11S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.L11S	SIDM01387	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.S32C	ACH-000445	Brain Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	0.0833
p.G20V	NCI-H2291	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7532
p.T10R	ABC-1	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.T10R	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.H27N	COLO-741	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.2222
p.H27N	U031	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.2222
p.L30I	NCI-H841	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1389
p.G33V	NCI-H2291	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.M22I	SK-GT-4	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43290	U4/U6.U5 tri-snRNP-associated protein 1	DEG_SPOP_SBC_1	622:626	ASSTT	SPOP	0.9972	More...
P02724	Glycophorin-A	DEG_SPOP_SBC_1	19:23	ASSTT	SPOP	0.916	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	646:650	ASSTT	SPOP	0.8976	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1617:1621	ASSTT	SPOP	0.9919	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	1181:1185	ASSTT	SPOP	0.7757	More...
P49683	Prolactin-releasing peptide receptor	DEG_SPOP_SBC_1	2:6	ASSTT	SPOP	0.9979	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1095:1099	ASSTT	SPOP	0.9514	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2640:2644	ASSTT	SPOP	0.9344	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	578:582	ASSTT	SPOP	0.9349	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4079:4083	ASSTT	SPOP	0.9127	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	731:735	ASSTT	SPOP	0.8162	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3480:3484	ASSTT	SPOP	0.8983	More...
Q8IX21	SMC5-SMC6 complex localization factor protein 2	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9928	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1244:1248	ASSTT	SPOP	0.9839	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	152:156	ASSTT	SPOP	0.7948	More...
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_SPOP_SBC_1	662:666	ASSTT	SPOP	0.9983	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1194:1198	ASSTT	SPOP	0.9483	More...
Q9C0C9		DEG_SPOP_SBC_1	498:502	ASSTT	SPOP	0.9902	More...
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SPOP_SBC_1	250:254	ASSTT	SPOP	0.9353	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1624:1628	ASSTT	SPOP	0.9708	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1873:1877	ASSTT	SPOP	0.9842	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3181:3185	ASSTT	SPOP	0.9778	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3430:3434	ASSTT	SPOP	0.9869	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4264:4268	ASSTT	SPOP	0.9753	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4513:4517	ASSTT	SPOP	0.9852	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4706:4710	ASSTT	SPOP	0.5037	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	83:87	ASSTT	SPOP	0.9996	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	154:158	ASSTT	SPOP	0.9742	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1605:1609	ASSTT	SPOP	0.5454	More...
A6NEY3	Putative golgin subfamily A member 6-like protein 3	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.7368	More...
A6NI86	Golgin subfamily A member 6-like protein 10	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.832	More...
H0YKK7	Putative golgin subfamily A member 6-like protein 19	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.713	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	280:284	ASSTT	SPOP	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTT

Degron related mutations and impact score

Drug responses associated with GYPA mutations

All proteins holding degron of ASSTT