DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 462:466

E3 ligase: SPOP

DEGRON score: 0.9801

ASA_SCORE: 81

COIL: 0.8428

CONS_SCORE: 0

DSS_SCORE: 0.6353

HELIX: 0.0276

FCONS_SCORE: 0

RIG_SCORE: 0.5927

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P475T	DO222827	BTCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.P475T	DO229061	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.T455I	DO222509	ESCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.1389
p.H469R	DO228005	LAML	ICGC	ASSTT	DEG_SPOP_SBC_1	0.25
p.H469R	DO229051	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.25
p.H469R	DO229055	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.25
p.H469R	DO229088	THCA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.25
p.P452S	DO220874	MELA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.P458T	SIDM00120	Prostate Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.2222
p.P458T	DU-145	prostate	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.2222
p.E476K	SIDM00650	Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.E476K	SIDM01681	Non-Cancerous	GDSC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.S459L	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.25
p.S459L	NCI-H2087	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.25
p.V462D	SIDM00092	Ovarian Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.7785
p.V462D	OVCAR-4	ovary	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7785
p.D464G	SIDM00027	Kidney Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.7198
p.D464G	SK-NEP-1	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7198
p.T466M	SIDM00402	Bladder Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.7423
p.T466M	RT-112	urinary_tract	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7423
p.A454D	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.A454D	NCI-H1993	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.M475V	SIDM00609	Kidney Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.M475V	KMRC-20	kidney	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.L467M	ACH-001685	Lymphoma	CCLE	ASSTT	DEG_SPOP_SBC_1	0.3056
p.S454A	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.S464F	KYSE-140	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.7982
p.P456A	MDA-MB-468	breast	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1667
p.P456A	CAL-72	bone	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43290	U4/U6.U5 tri-snRNP-associated protein 1	DEG_SPOP_SBC_1	622:626	ASSTT	SPOP	0.9972	More...
P02724	Glycophorin-A	DEG_SPOP_SBC_1	19:23	ASSTT	SPOP	0.916	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	646:650	ASSTT	SPOP	0.8976	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1617:1621	ASSTT	SPOP	0.9919	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	1181:1185	ASSTT	SPOP	0.7757	More...
P49683	Prolactin-releasing peptide receptor	DEG_SPOP_SBC_1	2:6	ASSTT	SPOP	0.9979	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1095:1099	ASSTT	SPOP	0.9514	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2640:2644	ASSTT	SPOP	0.9344	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	578:582	ASSTT	SPOP	0.9349	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4079:4083	ASSTT	SPOP	0.9127	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	731:735	ASSTT	SPOP	0.8162	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3480:3484	ASSTT	SPOP	0.8983	More...
Q8IX21	SMC5-SMC6 complex localization factor protein 2	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9928	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1244:1248	ASSTT	SPOP	0.9839	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	152:156	ASSTT	SPOP	0.7948	More...
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_SPOP_SBC_1	662:666	ASSTT	SPOP	0.9983	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1194:1198	ASSTT	SPOP	0.9483	More...
Q9C0C9		DEG_SPOP_SBC_1	498:502	ASSTT	SPOP	0.9902	More...
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SPOP_SBC_1	250:254	ASSTT	SPOP	0.9353	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1624:1628	ASSTT	SPOP	0.9708	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1873:1877	ASSTT	SPOP	0.9842	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3181:3185	ASSTT	SPOP	0.9778	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3430:3434	ASSTT	SPOP	0.9869	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4264:4268	ASSTT	SPOP	0.9753	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4513:4517	ASSTT	SPOP	0.9852	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4706:4710	ASSTT	SPOP	0.5037	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	83:87	ASSTT	SPOP	0.9996	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	154:158	ASSTT	SPOP	0.9742	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1605:1609	ASSTT	SPOP	0.5454	More...
A6NEY3	Putative golgin subfamily A member 6-like protein 3	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.7368	More...
A6NI86	Golgin subfamily A member 6-like protein 10	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.832	More...
H0YKK7	Putative golgin subfamily A member 6-like protein 19	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.713	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	280:284	ASSTT	SPOP	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of ASSTT