DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 3181:3185

E3 ligase: SPOP

DEGRON score: 0.9778

ASA_SCORE: 79.78

COIL: 0.7888

CONS_SCORE: 0

DSS_SCORE: 0.6513

HELIX: 0.0226

FCONS_SCORE: 0

RIG_SCORE: 0.6393

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F3179L	DO228912	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	0.2778
p.A3182E	SIDM01095	Rhabdomyosarcoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.7701
p.G3178S	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.25
p.G3178S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.25
p.G3178S	SIDM00930	Osteosarcoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.25
p.G3178S	HCE-4	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.25
p.P3187L	SIDM00681	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.2778
p.P3187L	SIDM01641	Non-Cancerous	GDSC	ASSTT	DEG_SPOP_SBC_1	0.2778
p.T3173A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.T3173A	H513	pleura	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1111
p.G3178D	SIDM00567	Other Solid Cancers	GDSC	ASSTT	DEG_SPOP_SBC_1	0.25
p.G3178D	ONS-76	central_nervous_system	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.25
p.D3172N	SIDM00954	Breast Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.S3176T	SIDM00534	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.S3176T	HT-115	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1944
p.S3184P	647-V	urinary_tract	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	HC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	SHP-77	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	PANC-08-13	pancreas	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	LoVo	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	OAW-42	ovary	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	Hs940-T	skin	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	NCI-H1623	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	MOG-G-UVW	central_nervous_system	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	HT-1197	urinary_tract	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	COR-L23	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	H2869	pleura	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	NCI-H2227	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	Capan-2	pancreas	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	HCC2998	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	WM278	skin	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	SCC-15	upper_aerodigestive_tract	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	NCI-H446	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	Hs-445	haematopoietic_and_lymphoid_tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	NCI-H226	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.S3184P	NCI-H358	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.6752
p.G3195A	HuH-7	liver	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.G3195A	KYSE-510	oesophagus	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0556
p.S3194R	RERF-LC-Sq1	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.0833
p.S3176P	SW48	large_intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43290	U4/U6.U5 tri-snRNP-associated protein 1	DEG_SPOP_SBC_1	622:626	ASSTT	SPOP	0.9972	More...
P02724	Glycophorin-A	DEG_SPOP_SBC_1	19:23	ASSTT	SPOP	0.916	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	646:650	ASSTT	SPOP	0.8976	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1617:1621	ASSTT	SPOP	0.9919	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	1181:1185	ASSTT	SPOP	0.7757	More...
P49683	Prolactin-releasing peptide receptor	DEG_SPOP_SBC_1	2:6	ASSTT	SPOP	0.9979	More...
Q07889	Son of sevenless homolog 1	DEG_SPOP_SBC_1	1095:1099	ASSTT	SPOP	0.9514	More...
Q15751	Probable E3 ubiquitin-protein ligase HERC1	DEG_SPOP_SBC_1	2640:2644	ASSTT	SPOP	0.9344	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	578:582	ASSTT	SPOP	0.9349	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4079:4083	ASSTT	SPOP	0.9127	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	731:735	ASSTT	SPOP	0.8162	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	3480:3484	ASSTT	SPOP	0.8983	More...
Q8IX21	SMC5-SMC6 complex localization factor protein 2	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9928	More...
Q8NI27	THO complex subunit 2	DEG_SPOP_SBC_1	1244:1248	ASSTT	SPOP	0.9839	More...
Q8TBK6	Zinc finger CCHC domain-containing protein 10	DEG_SPOP_SBC_1	152:156	ASSTT	SPOP	0.7948	More...
Q92841	Probable ATP-dependent RNA helicase DDX17	DEG_SPOP_SBC_1	662:666	ASSTT	SPOP	0.9983	More...
Q9C091	GREB1-like protein	DEG_SPOP_SBC_1	1194:1198	ASSTT	SPOP	0.9483	More...
Q9C0C9		DEG_SPOP_SBC_1	498:502	ASSTT	SPOP	0.9902	More...
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SPOP_SBC_1	250:254	ASSTT	SPOP	0.9353	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	462:466	ASSTT	SPOP	0.9801	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1624:1628	ASSTT	SPOP	0.9708	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	1873:1877	ASSTT	SPOP	0.9842	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3181:3185	ASSTT	SPOP	0.9778	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	3430:3434	ASSTT	SPOP	0.9869	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4264:4268	ASSTT	SPOP	0.9753	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4513:4517	ASSTT	SPOP	0.9852	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4706:4710	ASSTT	SPOP	0.5037	More...
Q9UNF1	Melanoma-associated antigen D2	DEG_SPOP_SBC_1	83:87	ASSTT	SPOP	0.9996	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	154:158	ASSTT	SPOP	0.9742	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1605:1609	ASSTT	SPOP	0.5454	More...
A6NEY3	Putative golgin subfamily A member 6-like protein 3	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.7368	More...
A6NI86	Golgin subfamily A member 6-like protein 10	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.832	More...
H0YKK7	Putative golgin subfamily A member 6-like protein 19	DEG_SPOP_SBC_1	79:83	ASSTT	SPOP	0.713	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	280:284	ASSTT	SPOP	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSTT

Degron related mutations and impact score

Drug responses associated with MUC12 mutations

All proteins holding degron of ASSTT