DegronMD - Q9UGI6(KCNN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N259T	TCGA-19-5956	GBM	TCGA	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.N259T	DO13863	GBM	ICGC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1944
p.H243N	TCGA-AP-A5FX	UCEC	TCGA	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.H243N	DO49072	UCEC	ICGC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.S729N	TCGA-CA-6717	COAD	TCGA	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.S729N	TCGA-CA-6717	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.S729N	DO8264	COAD	ICGC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.S729N	DO8264	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.S729N	ACH-002388	Skin Cancer	CCLE	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.S729N	ACH-002388	Skin Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.P722S	TCGA-EE-A2MR	SKCM	TCGA	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6752
p.P722S	DO37819	SKCM	ICGC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6752
p.P722S	ACH-000981	Leukemia	CCLE	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6752
p.P722S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6752
p.P708S	TCGA-GN-A269	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1111
p.P708S	DO37483	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.1111
p.G715V	TCGA-W3-AA1W	SKCM	TCGA	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1389
p.G715V	TCGA-W3-AA1W	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.3056
p.G715V	DO51277	SKCM	ICGC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1389
p.G715V	DO51277	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.3056
p.A250T	DO234462	ESAD	ICGC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7139
p.A250T	SIDM01765	Osteosarcoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7139
p.A250T	ACH-000529	Non-Cancerous	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.7139
p.T723N	DO229027	LICA	ICGC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7055
p.P737L	SIDM02059	Colorectal Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.P737L	SIDM00698	Small Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.P737L	NCI-H146	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.P737S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.P737S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.S251G	SIDM00845	Burkitt's Lymphoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.S251G	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.S251G	SIDM01519	Head and Neck Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.S251G	ACH-000786	Lymphoma	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.S251G	ACH-000992	Head and Neck Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.S251G	Daudi	haematopoietic and lymphoid tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.5882
p.N242D	SIDM00353	Other Sarcomas	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.N242D	ACH-000505	Sarcoma	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.N242D	RKN	ovary	COSMIC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1111
p.P256L	SIDM01112	Osteosarcoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.P256L	ACH-000748	Bone Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.P256L	SJSA-1	bone	COSMIC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.2778
p.S251R	SIDM00040	Gastric Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6316
p.S251R	ACH-002202	Gastric Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6316
p.S251R	TMK-1	stomach	COSMIC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation altering degron motif	0.6316
p.I729T	SIDM01110	Hepatocellular Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.I729T	SIDM01110	Hepatocellular Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.I729T	SIDM00140	Melanoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.I729T	SIDM00140	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.I729T	SK-HEP-1	liver	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.I729T	SK-HEP-1	liver	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.I729T	COLO-792	skin	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.I729T	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.0833
p.G712R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.G712R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.2222
p.G712R	NCI-H1703	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.0556
p.G712R	NCI-H1703	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.2222
p.S735F	SIDM00524	Small Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1111
p.S735F	DMS-79	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1111
p.R261W	SIDM00980	Gastric Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.R261W	ACH-000948	Gastric Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.R261W	23132-87	stomach	COSMIC	ASSTT	DEG_SPOP_SBC_1	250:254	Mutation rewiring degron network	0.1389
p.P722L	ACH-000506	Lung Cancer	CCLE	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6471
p.P722L	NCI-H146	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6471
p.S720F	ACH-000703	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation altering degron motif	0.7982
p.S720F	DMS-79	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation altering degron motif	0.7982
p.I714T	COLO-792	skin	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1111
p.I714T	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.2778
p.I714T	SK-HEP-1	liver	COSMIC	PTPYTS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1111
p.I714T	SK-HEP-1	liver	COSMIC	VSSTS	DEG_SPOP_SBC_1	716:720	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNN3

UniProt ID: Q9UGI6

Entrez ID: 3782

Protein name: Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa 3) (SKCa3) (KCa2.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNN3 in