DegronMD

Uniprot ID: Q9UGI6

Source protein: Small conductance calcium-activated potassium channel protein 3

Source gene: KCNN3

Class: DEG_SCF_FBW7_1

Location: 722:727

E3 ligase: FBXW7

DEGRON score: 0.9652

ASA_SCORE: 93.3667

COIL: 0.9468

CONS_SCORE: 0.2602

DSS_SCORE: 0.5627

HELIX: 0.0218

FCONS_SCORE: 0.6151

RIG_SCORE: 0.677

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S729N	TCGA-CA-6717	COAD	TCGA	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.S729N	DO8264	COAD	ICGC	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.S729N	ACH-002388	Skin Cancer	CCLE	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.P722S	TCGA-EE-A2MR	SKCM	TCGA	PTPYTS	DEG_SCF_FBW7_1	0.6752
p.P722S	DO37819	SKCM	ICGC	PTPYTS	DEG_SCF_FBW7_1	0.6752
p.P722S	ACH-000981	Leukemia	CCLE	PTPYTS	DEG_SCF_FBW7_1	0.6752
p.P722S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.6752
p.G715V	TCGA-W3-AA1W	SKCM	TCGA	PTPYTS	DEG_SCF_FBW7_1	0.1389
p.G715V	DO51277	SKCM	ICGC	PTPYTS	DEG_SCF_FBW7_1	0.1389
p.T723N	DO229027	LICA	ICGC	PTPYTS	DEG_SCF_FBW7_1	0.7055
p.P737L	SIDM02059	Colorectal Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.P737L	SIDM00698	Small Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.P737L	NCI-H146	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.P737S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.P737S	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.I729T	SIDM01110	Hepatocellular Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.I729T	SIDM00140	Melanoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.I729T	SK-HEP-1	liver	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.I729T	COLO-792	skin	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.2778
p.G712R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.G712R	NCI-H1703	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.0556
p.S735F	SIDM00524	Small Cell Lung Carcinoma	GDSC	PTPYTS	DEG_SCF_FBW7_1	0.1111
p.S735F	DMS-79	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.1111
p.P722L	ACH-000506	Lung Cancer	CCLE	PTPYTS	DEG_SCF_FBW7_1	0.6471
p.P722L	NCI-H146	lung	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.6471
p.I714T	COLO-792	skin	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.1111
p.I714T	SK-HEP-1	liver	COSMIC	PTPYTS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPYTS

Degron related mutations and impact score

Drug responses associated with KCNN3 mutations

All proteins holding degron of PTPYTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SCF_FBW7_1	722:727	PTPYTS	FBXW7	0.9652	More...