DegronMD

Uniprot ID: Q9UGI6

Source protein: Small conductance calcium-activated potassium channel protein 3

Source gene: KCNN3

Class: DEG_SPOP_SBC_1

Location: 716:720

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 85.3

COIL: 0.9504

CONS_SCORE: 0.3975

DSS_SCORE: 0.4304

HELIX: 0.0222

FCONS_SCORE: 1.0629

RIG_SCORE: 0.6625

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S729N	TCGA-CA-6717	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	0.0833
p.S729N	DO8264	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	0.0833
p.S729N	ACH-002388	Skin Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	0.0833
p.P708S	TCGA-GN-A269	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	0.1111
p.P708S	DO37483	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	0.1111
p.G715V	TCGA-W3-AA1W	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	0.3056
p.G715V	DO51277	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	0.3056
p.I729T	SIDM01110	Hepatocellular Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	0.0833
p.I729T	SIDM00140	Melanoma	GDSC	VSSTS	DEG_SPOP_SBC_1	0.0833
p.I729T	SK-HEP-1	liver	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.0833
p.I729T	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.0833
p.G712R	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	0.2222
p.G712R	NCI-H1703	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.2222
p.S720F	ACH-000703	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	0.7982
p.S720F	DMS-79	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.7982
p.I714T	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.2778
p.I714T	SK-HEP-1	liver	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15195	Villin-like protein	DEG_SPOP_SBC_1	785:789	VSSTS	SPOP	0.9063	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	463:467	VSSTS	SPOP	0.9197	More...
P32246	C-C chemokine receptor type 1	DEG_SPOP_SBC_1	339:343	VSSTS	SPOP	0.8417	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	984:988	VSSTS	SPOP	0.9993	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	2497:2501	VSSTS	SPOP	0.9395	More...
P98194	Calcium-transporting ATPase type 2C member 1	DEG_SPOP_SBC_1	909:913	VSSTS	SPOP	0.7013	More...
Q14444	Caprin-1	DEG_SPOP_SBC_1	435:439	VSSTS	SPOP	0.9876	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	150:154	VSSTS	SPOP	0.7703	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	601:605	VSSTS	SPOP	0.9993	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1552:1556	VSSTS	SPOP	0.936	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	1675:1679	VSSTS	SPOP	0.8575	More...
Q8IZ20	Tissue-resident T-cell transcription regulator protein ZNF683	DEG_SPOP_SBC_1	496:500	VSSTS	SPOP	0.9005	More...
Q8N9Q2	Protein SREK1IP1	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9807	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	664:668	VSSTS	SPOP	0.9924	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	88:92	VSSTS	SPOP	0.985	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	446:450	VSSTS	SPOP	0.9902	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1217:1221	VSSTS	SPOP	0.755	More...
Q9H2Y7	Zinc finger protein 106	DEG_SPOP_SBC_1	1475:1479	VSSTS	SPOP	0.8958	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	610:614	VSSTS	SPOP	0.92	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	175:179	VSSTS	SPOP	0.9944	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	655:659	VSSTS	SPOP	0.9712	More...
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_SPOP_SBC_1	218:222	VSSTS	SPOP	0.9877	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	608:612	VSSTS	SPOP	0.9192	More...
Q9UGI6	Small conductance calcium-activated potassium channel protein 3	DEG_SPOP_SBC_1	716:720	VSSTS	SPOP	0.9889	More...
Q9Y2W2	WW domain-binding protein 11	DEG_SPOP_SBC_1	249:253	VSSTS	SPOP	0.9947	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	667:671	VSSTS	SPOP	0.9399	More...
P52737	Zinc finger protein 136	DEG_SPOP_SBC_1	430:434	VSSTS	SPOP	0.9793	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.9827	More...
Q6TDP4	Kelch-like protein 17	DEG_SPOP_SBC_1	637:641	VSSTS	SPOP	0.7137	More...
Q7Z7J5	Developmental pluripotency-associated protein 2	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9982	More...
Q99666	RANBP2-like and GRIP domain-containing protein 5/6	DEG_SPOP_SBC_1	1521:1525	VSSTS	SPOP	0.7817	More...
A6NKT7	RanBP2-like and GRIP domain-containing protein 3	DEG_SPOP_SBC_1	1522:1526	VSSTS	SPOP	0.8024	More...
O14715	RANBP2-like and GRIP domain-containing protein 8	DEG_SPOP_SBC_1	1521:1525	VSSTS	SPOP	0.7144	More...
P0DJD1	RANBP2-like and GRIP domain-containing protein 2	DEG_SPOP_SBC_1	1514:1518	VSSTS	SPOP	0.9568	More...
Q5JQS6	Germinal center-associated signaling and motility-like protein	DEG_SPOP_SBC_1	50:54	VSSTS	SPOP	0.9925	More...
Q7Z3J3	RanBP2-like and GRIP domain-containing protein 4	DEG_SPOP_SBC_1	1522:1526	VSSTS	SPOP	0.869	More...
C9J202	Putative glycosyltransferase ALG1L2	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.7087	More...
O15544	Protein GR6	DEG_SPOP_SBC_1	16:20	VSSTS	SPOP	0.9463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTS

Degron related mutations and impact score

Drug responses associated with KCNN3 mutations

All proteins holding degron of VSSTS