DegronMD - Q9Y2W2(WBP11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D263G	TCGA-24-1464	OV	TCGA	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.D263G	DO29418	OV	ICGC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0556
p.P455S	TCGA-58-8386	LUSC	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.5641
p.P455S	DO45537	LUSC	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.5641
p.P453S	TCGA-AA-3984	COAD	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.5641
p.P453S	DO9002	COAD	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.5641
p.H245R	TCGA-AD-A5EJ	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.H245R	DO50090	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.H245R	SIDM01045	Endometrial Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.H245R	ACH-000978	Endometrial/Uterine Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.H245R	EN	endometrium	COSMIC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.P259T	TCGA-AX-A06F	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P259T	DO228948	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P259T	DO41752	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1667
p.P467L	TCGA-EE-A20C	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.P467L	DO47665	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.P467L	ACH-001516	Cervical Cancer	CCLE	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.P467S	TCGA-EE-A20C	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.P467S	DO47665	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.P459L	TCGA-FW-A3R5	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.3056
p.P459L	DO37406	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.3056
p.P444Q	DO228952	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.P444Q	DO229028	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.P445T	DO229026	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1944
p.P467F	DO222775	MELA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.F441L	DO50660	ORCA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.0833
p.D247G	SIDM00170	Head and Neck Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.D247G	ACH-000682	Head and Neck Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2778
p.L450I	ACH-000786	Lymphoma	CCLE	LRGPLPRLL	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6063

Kaplan plot for WBP11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WBP11

UniProt ID: Q9Y2W2

Entrez ID: 51729

Protein name: WW domain-binding protein 11 (WBP-11) (Npw38-binding protein) (NpwBP) (SH3 domain-binding protein SNP70) (Splicing factor that interacts with PQBP-1 and PP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WBP11 in