DegronMD

Uniprot ID: Q9Y2W2

Source protein: WW domain-binding protein 11

Source gene: WBP11

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9145

ASA_SCORE: 107.9333

COIL: 0.9646

CONS_SCORE: 0.7549

DSS_SCORE: 0.7635

HELIX: 0.016

FCONS_SCORE: 1.0503

RIG_SCORE: 0.5519

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P455S	TCGA-58-8386	LUSC	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	0.5641
p.P455S	DO45537	LUSC	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.5641
p.P453S	TCGA-AA-3984	COAD	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	0.5641
p.P453S	DO9002	COAD	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.5641
p.P467L	TCGA-EE-A20C	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.P467L	DO47665	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.P467L	ACH-001516	Cervical Cancer	CCLE	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.P467S	TCGA-EE-A20C	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.P467S	DO47665	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.P459L	TCGA-FW-A3R5	SKCM	TCGA	LRGPLPRLL	DEG_APCC_DBOX_1	0.3056
p.P459L	DO37406	SKCM	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.3056
p.P444Q	DO228952	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.1667
p.P444Q	DO229028	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.1667
p.P445T	DO229026	LICA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.1944
p.P467F	DO222775	MELA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.F441L	DO50660	ORCA	ICGC	LRGPLPRLL	DEG_APCC_DBOX_1	0.0833
p.L450I	ACH-000786	Lymphoma	CCLE	LRGPLPRLL	DEG_APCC_DBOX_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2W2	WW domain-binding protein 11	DEG_APCC_DBOX_1	450:458	LRGPLPRLL	APC,CDC20,FZR1	0.9145	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons