DegronMD - Q4AC94(C2CD3)

FUNCTION: Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriol... View more >>

GO - Biological processes (BP): brain development [GO:0007420]; centriole elongation [GO:0061511]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; neural plate axis specification [GO:0021997]; neural tube development [GO:0021915]; no... View more >>

GO - Molecular function (MF):

GO - Cellular component (CC): centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1162K	TCGA-95-7948	LUAD	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.7022
p.E1162K	DO25133	LUAD	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.7022
p.K1888M	TCGA-XF-AAN3	BLCA	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation altering degron motif	0.6951
p.K1888M	DO219053	BLCA	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation altering degron motif	0.6951
p.E1162Q	TCGA-E7-A7XN	BLCA	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6744
p.E1162Q	DO51878	BLCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6744
p.S151L	TCGA-Q1-A73O	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.6556
p.S151L	DO51612	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.6556
p.L1155I	TCGA-BS-A0UF	UCEC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6063
p.L1155I	DO41488	UCEC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6063
p.S1606Y	TCGA-AP-A1DV	UCEC	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation blocking phosphorylation signal	0.5833
p.S1606Y	DO43186	UCEC	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation blocking phosphorylation signal	0.5833
p.F1153S	DO229275	THCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.2778
p.T1610N	TCGA-20-1685	OV	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.T1610N	DO29688	OV	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1620K	TCGA-85-A4CL	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1620K	DO45454	LUSC	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1620D	DO233170	GACA	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.G158R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G158R	ACH-000980	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 48 entries

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Kaplan plot for C2CD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2CD3

UniProt ID: Q4AC94

Entrez ID: 26005

Protein name: C2 domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2CD3 in