DegronMD - Q4AC94(C2CD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1610N	TCGA-20-1685	OV	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.T1610N	DO29688	OV	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1620K	TCGA-85-A4CL	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1620K	DO45454	LUSC	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.E1162K	TCGA-95-7948	LUAD	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.7022
p.E1162K	DO25133	LUAD	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.7022
p.L1167S	TCGA-A5-A2K3	UCEC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1944
p.L1167S	DO43899	UCEC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1944
p.Q1879H	TCGA-AG-A002	READ	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1389
p.S1606Y	TCGA-AP-A1DV	UCEC	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation blocking phosphorylation signal	0.5833
p.S1606Y	DO43186	UCEC	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation blocking phosphorylation signal	0.5833
p.R1622C	TCGA-BR-8361	STAD	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1944
p.R1622C	DO48032	STAD	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1944
p.L1155I	TCGA-BS-A0UF	UCEC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6063
p.L1155I	DO41488	UCEC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6063
p.G1149E	TCGA-CV-6952	HNSC	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1667
p.G1149E	DO14240	HNSC	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1667
p.T1624M	TCGA-D8-A1XF	BRCA	TCGA	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1389
p.T1624M	DO4263	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1389
p.T1624M	SIDM00178	Melanoma	GDSC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1389
p.T1624M	ACH-002386	Skin Cancer	CCLE	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1389
p.T1880P	TCGA-DI-A1BU	UCEC	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1667
p.T1880P	DO42023	UCEC	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1667
p.E1162Q	TCGA-E7-A7XN	BLCA	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6744
p.E1162Q	DO51878	BLCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation altering degron motif	0.6744
p.T1880I	TCGA-ER-A19C	SKCM	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1667
p.T1880I	DO47353	SKCM	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1667
p.N1169S	TCGA-IB-7651	PAAD	TCGA	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1389
p.N1169S	DO46657	PAAD	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.1389
p.S1881C	TCGA-JY-A6FD	ESCA	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1944
p.S151L	TCGA-Q1-A73O	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.6556
p.S151L	DO51612	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.6556
p.K1888M	TCGA-XF-AAN3	BLCA	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation altering degron motif	0.6951
p.K1888M	DO219053	BLCA	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation altering degron motif	0.6951
p.E1620D	DO233170	GACA	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.25
p.L1623M	DO229019	LICA	ICGC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1667
p.T1880N	DO229031	LICA	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1667
p.F1153S	DO229275	THCA	ICGC	LPLTPRIE	DEG_SCF_FBW7_2	1155:1162	Mutation rewiring degron network	0.2778
p.H141D	SIDM00460	B-Cell Non-Hodgkin's Lymphoma	GDSC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.H141D	SIDM01168	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.H141D	OCI-LY-19	haematopoietic and lymphoid tissue	COSMIC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.H141D	SW626	ovary	COSMIC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0833
p.R1622H	SIDM00450	Acute Myeloid Leukemia	GDSC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1944
p.R1622H	PL-21	haematopoietic and lymphoid tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	1613:1617	Mutation rewiring degron network	0.1944
p.G158R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G158R	ACH-000980	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G158R	NCI-H1155	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.Y1899C	ACH-000985	Colon/Colorectal Cancer	CCLE	LRKNLSELD	DEG_APCC_DBOX_1	1886:1894	Mutation rewiring degron network	0.1944

Kaplan plot for C2CD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C2CD3

UniProt ID: Q4AC94

Entrez ID: 26005

Protein name: C2 domain-containing protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C2CD3 in