DegronMD

Uniprot ID: Q4AC94

Source protein: C2 domain-containing protein 3

Source gene: C2CD3

Class: DEG_APCC_DBOX_1

Location: 1886:1894

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9499

ASA_SCORE: 84.7556

COIL: 0.3071

CONS_SCORE: 0.5513

DSS_SCORE: 0.2679

HELIX: 0.694

FCONS_SCORE: 1.2809

RIG_SCORE: 0.7828

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1879H	TCGA-AG-A002	READ	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	0.1389
p.T1880P	TCGA-DI-A1BU	UCEC	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	0.1667
p.T1880P	DO42023	UCEC	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	0.1667
p.T1880I	TCGA-ER-A19C	SKCM	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	0.1667
p.T1880I	DO47353	SKCM	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	0.1667
p.S1881C	TCGA-JY-A6FD	ESCA	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	0.1944
p.K1888M	TCGA-XF-AAN3	BLCA	TCGA	LRKNLSELD	DEG_APCC_DBOX_1	0.6951
p.K1888M	DO219053	BLCA	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	0.6951
p.T1880N	DO229031	LICA	ICGC	LRKNLSELD	DEG_APCC_DBOX_1	0.1667
p.Y1899C	ACH-000985	Colon/Colorectal Cancer	CCLE	LRKNLSELD	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4AC94	C2 domain-containing protein 3	DEG_APCC_DBOX_1	1886:1894	LRKNLSELD	APC,CDC20,FZR1	0.9499	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons