DegronMD

Uniprot ID: Q4AC94

Source protein: C2 domain-containing protein 3

Source gene: C2CD3

Class: DEG_SPOP_SBC_1

Location: 1613:1617

E3 ligase: SPOP

DEGRON score: 0.9853

ASA_SCORE: 74.9

COIL: 0.9042

CONS_SCORE: 0.2718

DSS_SCORE: 0.5172

HELIX: 0.0434

FCONS_SCORE: 0.9358

RIG_SCORE: 0.7027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1610N	TCGA-20-1685	OV	TCGA	PCSST	DEG_SPOP_SBC_1	0.25
p.T1610N	DO29688	OV	ICGC	PCSST	DEG_SPOP_SBC_1	0.25
p.E1620K	TCGA-85-A4CL	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	0.25
p.E1620K	DO45454	LUSC	ICGC	PCSST	DEG_SPOP_SBC_1	0.25
p.S1606Y	TCGA-AP-A1DV	UCEC	TCGA	PCSST	DEG_SPOP_SBC_1	0.5833
p.S1606Y	DO43186	UCEC	ICGC	PCSST	DEG_SPOP_SBC_1	0.5833
p.R1622C	TCGA-BR-8361	STAD	TCGA	PCSST	DEG_SPOP_SBC_1	0.1944
p.R1622C	DO48032	STAD	ICGC	PCSST	DEG_SPOP_SBC_1	0.1944
p.T1624M	TCGA-D8-A1XF	BRCA	TCGA	PCSST	DEG_SPOP_SBC_1	0.1389
p.T1624M	DO4263	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1389
p.T1624M	SIDM00178	Melanoma	GDSC	PCSST	DEG_SPOP_SBC_1	0.1389
p.T1624M	ACH-002386	Skin Cancer	CCLE	PCSST	DEG_SPOP_SBC_1	0.1389
p.E1620D	DO233170	GACA	ICGC	PCSST	DEG_SPOP_SBC_1	0.25
p.L1623M	DO229019	LICA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1667
p.R1622H	SIDM00450	Acute Myeloid Leukemia	GDSC	PCSST	DEG_SPOP_SBC_1	0.1944
p.R1622H	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_SPOP_SBC_1	603:607	PCSST	SPOP	0.9643	More...
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_SPOP_SBC_1	7:11	PCSST	SPOP	0.9874	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	1613:1617	PCSST	SPOP	0.9853	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	169:173	PCSST	SPOP	0.9935	More...
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SPOP_SBC_1	215:219	PCSST	SPOP	0.7069	More...
Q9BZR9	E3 ubiquitin-protein ligase TRIM8	DEG_SPOP_SBC_1	418:422	PCSST	SPOP	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons