DegronMD

Uniprot ID: Q9BZR9

Source protein: E3 ubiquitin-protein ligase TRIM8

Source gene: TRIM8

Class: DEG_SPOP_SBC_1

Location: 418:422

E3 ligase: SPOP

DEGRON score: 0.9893

ASA_SCORE: 66.72

COIL: 0.8276

CONS_SCORE: 0.4997

DSS_SCORE: 0.5897

HELIX: 0.1238

FCONS_SCORE: 1.0403

RIG_SCORE: 0.6512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S421C	TCGA-55-7570	LUAD	TCGA	PCSST	DEG_SPOP_SBC_1	0.7541
p.S421C	DO25280	LUAD	ICGC	PCSST	DEG_SPOP_SBC_1	0.7541
p.S412C	TCGA-DK-A1A3	BLCA	TCGA	PCSST	DEG_SPOP_SBC_1	0.1667
p.S412C	DO558	BLCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1667
p.P429L	TCGA-EY-A549	UCEC	TCGA	PCSST	DEG_SPOP_SBC_1	0.1389
p.P429L	DO48174	UCEC	ICGC	PCSST	DEG_SPOP_SBC_1	0.1389
p.A427V	TCGA-YD-A89C	SKCM	TCGA	PCSST	DEG_SPOP_SBC_1	0.1944
p.A427V	DO219501	SKCM	ICGC	PCSST	DEG_SPOP_SBC_1	0.1944
p.T422M	DO227802	COCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.7423
p.G413W	DO228948	LICA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1944
p.G413V	DO228948	LICA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1944
p.L416P	DO218878	SKCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.2778
p.L416P	DO218842	SKCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.2778
p.A432T	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCSST	DEG_SPOP_SBC_1	0.0556
p.A432T	ACH-002221	Lymphoma	CCLE	PCSST	DEG_SPOP_SBC_1	0.0556
p.A432T	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_SPOP_SBC_1	603:607	PCSST	SPOP	0.9643	More...
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_SPOP_SBC_1	7:11	PCSST	SPOP	0.9874	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	1613:1617	PCSST	SPOP	0.9853	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	169:173	PCSST	SPOP	0.9935	More...
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SPOP_SBC_1	215:219	PCSST	SPOP	0.7069	More...
Q9BZR9	E3 ubiquitin-protein ligase TRIM8	DEG_SPOP_SBC_1	418:422	PCSST	SPOP	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons