DegronMD

Uniprot ID: P10242

Source protein: Transcriptional activator Myb

Source gene: MYB

Class: DEG_SPOP_SBC_1

Location: 603:607

E3 ligase: SPOP

DEGRON score: 0.9643

ASA_SCORE: 65.88

COIL: 0.7482

CONS_SCORE: 0.2956

DSS_SCORE: 0.416

HELIX: 0.0546

FCONS_SCORE: 0.9577

RIG_SCORE: 0.6874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L615V	TCGA-34-8454	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	0.5556
p.Q598E	TCGA-85-A4CL	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	0.1944
p.Q598R	TCGA-EI-6507	READ	TCGA	PCSST	DEG_SPOP_SBC_1	0.1944
p.E609A	DO225218	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.2778
p.E609A	DO227939	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.2778
p.P607T	DO229578	PRAD	ICGC	PCSST	DEG_SPOP_SBC_1	0.7031
p.P609S	SIDM00007	Other Solid Cancers	GDSC	PCSST	DEG_SPOP_SBC_1	0.2778
p.P609S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.2778
p.P609L	SIDM00007	Other Solid Cancers	GDSC	PCSST	DEG_SPOP_SBC_1	0.2778
p.P609L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.2778
p.P593L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.5
p.P593S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.5
p.G614E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	0.1389
p.P606S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.6752
p.M617I	NCI-H661	lung	COSMIC	PCSST	DEG_SPOP_SBC_1	0.0556
p.G611E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	0.2222
p.P606L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_SPOP_SBC_1	603:607	PCSST	SPOP	0.9643	More...
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_SPOP_SBC_1	7:11	PCSST	SPOP	0.9874	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	1613:1617	PCSST	SPOP	0.9853	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	169:173	PCSST	SPOP	0.9935	More...
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SPOP_SBC_1	215:219	PCSST	SPOP	0.7069	More...
Q9BZR9	E3 ubiquitin-protein ligase TRIM8	DEG_SPOP_SBC_1	418:422	PCSST	SPOP	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons