DegronMD

Uniprot ID: Q96T88

Source protein: E3 ubiquitin-protein ligase UHRF1

Source gene: UHRF1

Class: DEG_SPOP_SBC_1

Location: 169:173

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 73.66

COIL: 0.9182

CONS_SCORE: 0.1974

DSS_SCORE: 0.5651

HELIX: 0.0414

FCONS_SCORE: 0.7769

RIG_SCORE: 0.6722

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S178F	SIDM00528	Breast Carcinoma	GDSC	PCSST	DEG_SPOP_SBC_1	0.1944
p.S178F	MDA-MB-361	breast	COSMIC	PCSST	DEG_SPOP_SBC_1	0.1944
p.S165F	MDA-MB-361	breast	COSMIC	PCSST	DEG_SPOP_SBC_1	0.6667
p.E179K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	0.1667
p.S183N	GP5d	large_intestine	COSMIC	PCSST	DEG_SPOP_SBC_1	0.0556
p.G175S	HEC-1	endometrium	COSMIC	PCSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_SPOP_SBC_1	603:607	PCSST	SPOP	0.9643	More...
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_SPOP_SBC_1	7:11	PCSST	SPOP	0.9874	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	1613:1617	PCSST	SPOP	0.9853	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	169:173	PCSST	SPOP	0.9935	More...
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SPOP_SBC_1	215:219	PCSST	SPOP	0.7069	More...
Q9BZR9	E3 ubiquitin-protein ligase TRIM8	DEG_SPOP_SBC_1	418:422	PCSST	SPOP	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons