DegronMD

Uniprot ID: Q99592

Source protein: Zinc finger and BTB domain-containing protein 18

Source gene: ZBTB18

Class: DEG_SPOP_SBC_1

Location: 215:219

E3 ligase: SPOP

DEGRON score: 0.7069

ASA_SCORE: 88.18

COIL: 0.8924

CONS_SCORE: 0.4819

DSS_SCORE: 0.4909

HELIX: 0.0682

FCONS_SCORE: 0.9658

RIG_SCORE: 0.6721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S227L	DO233247	GACA	ICGC	PCSST	DEG_SPOP_SBC_1	0.1111
p.A214T	DO233624	GACA	ICGC	PCSST	DEG_SPOP_SBC_1	0.75
p.G218A	DO231467	THCA	ICGC	PCSST	DEG_SPOP_SBC_1	0.754

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_SPOP_SBC_1	603:607	PCSST	SPOP	0.9643	More...
P59044	NACHT, LRR and PYD domains-containing protein 6	DEG_SPOP_SBC_1	7:11	PCSST	SPOP	0.9874	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	1613:1617	PCSST	SPOP	0.9853	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	169:173	PCSST	SPOP	0.9935	More...
Q99592	Zinc finger and BTB domain-containing protein 18	DEG_SPOP_SBC_1	215:219	PCSST	SPOP	0.7069	More...
Q9BZR9	E3 ubiquitin-protein ligase TRIM8	DEG_SPOP_SBC_1	418:422	PCSST	SPOP	0.9893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons