DegronMD - P10242(MYB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L615V	TCGA-34-8454	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	603:607	Mutation blocking ubiquitination signal	0.5556
p.K453E	TCGA-56-8307	LUSC	TCGA	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.K453E	DO219139	LUSC	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.Q598E	TCGA-85-A4CL	LUSC	TCGA	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.R454H	TCGA-AX-A1C5	UCEC	TCGA	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.R454H	DO41422	UCEC	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.Q598R	TCGA-EI-6507	READ	TCGA	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1944
p.E437Q	TCGA-MV-A51V	BLCA	TCGA	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1389
p.E437Q	DO474	BLCA	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1389
p.L456F	TCGA-Q1-A6DT	CESC	TCGA	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation substituting flanking lysine	0.2222
p.L456F	DO44342	CESC	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation substituting flanking lysine	0.2222
p.I441S	DO48566	BLCA	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.25
p.E609A	DO225218	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.E609A	DO227939	BRCA	ICGC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.Q434L	DO45219	LIRI	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.0556
p.K439N	DO218932	LUAD	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.K439N	NCI-H1876	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.S458L	DO222498	MELA	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.0556
p.P607T	DO229578	PRAD	ICGC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7031
p.E444D	DO37896	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation altering degron motif	0.6758
p.P436S	DO37746	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1111
p.L438M	DO37971	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.P448S	DO43306	UCEC	ICGC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation altering degron motif	0.6752
p.P609S	SIDM00007	Other Solid Cancers	GDSC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.P609S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.P609L	SIDM00007	Other Solid Cancers	GDSC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.P609L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2778
p.R454C	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.R454C	ACH-000858	Lung Cancer	CCLE	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.R454C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.K442N	ACH-000586	Lung Cancer	CCLE	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation blocking ubiquitination signal	0.7222
p.K442N	NCI-H1876	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation blocking ubiquitination signal	0.7222
p.R457G	MFE-319	endometrium	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.0833
p.P453L	MCC13	skin	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.P453S	MCC13	skin	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1944
p.P593L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation blocking ubiquitination signal	0.5
p.R438C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.R454G	MFE-319	endometrium	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.1667
p.P593S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation blocking ubiquitination signal	0.5
p.R451C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation rewiring degron network	0.25
p.G614E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.1389
p.P606S	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.6752
p.M617I	NCI-H661	lung	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.0556
p.G611E	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation rewiring degron network	0.2222
p.P606L	MCC13	skin	COSMIC	PCSST	DEG_SPOP_SBC_1	603:607	Mutation altering degron motif	0.7582
p.S447F	SN12C	kidney	COSMIC	QKENT	DEG_APCC_KENBOX_2	444:448	Mutation altering degron motif	0.7982

Kaplan plot for MYB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYB

UniProt ID: P10242

Entrez ID: 4602

Protein name: Transcriptional activator Myb (Proto-oncogene c-Myb)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MYB in