DegronMD

Uniprot ID: P10242

Source protein: Transcriptional activator Myb

Source gene: MYB

Class: DEG_APCC_KENBOX_2

Location: 444:448

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9949

ASA_SCORE: 113.1

COIL: 0.859

CONS_SCORE: 0.273

DSS_SCORE: 0.5423

HELIX: 0.1004

FCONS_SCORE: 0.8685

RIG_SCORE: 0.7853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K453E	TCGA-56-8307	LUSC	TCGA	QKENT	DEG_APCC_KENBOX_2	0.1944
p.K453E	DO219139	LUSC	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1944
p.R454H	TCGA-AX-A1C5	UCEC	TCGA	QKENT	DEG_APCC_KENBOX_2	0.1667
p.R454H	DO41422	UCEC	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.E437Q	TCGA-MV-A51V	BLCA	TCGA	QKENT	DEG_APCC_KENBOX_2	0.1389
p.E437Q	DO474	BLCA	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1389
p.L456F	TCGA-Q1-A6DT	CESC	TCGA	QKENT	DEG_APCC_KENBOX_2	0.2222
p.L456F	DO44342	CESC	ICGC	QKENT	DEG_APCC_KENBOX_2	0.2222
p.I441S	DO48566	BLCA	ICGC	QKENT	DEG_APCC_KENBOX_2	0.25
p.Q434L	DO45219	LIRI	ICGC	QKENT	DEG_APCC_KENBOX_2	0.0556
p.K439N	DO218932	LUAD	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1944
p.K439N	NCI-H1876	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1944
p.S458L	DO222498	MELA	ICGC	QKENT	DEG_APCC_KENBOX_2	0.0556
p.E444D	DO37896	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	0.6758
p.P436S	DO37746	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1111
p.L438M	DO37971	SKCM	ICGC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.P448S	DO43306	UCEC	ICGC	QKENT	DEG_APCC_KENBOX_2	0.6752
p.R454C	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.R454C	ACH-000858	Lung Cancer	CCLE	QKENT	DEG_APCC_KENBOX_2	0.1667
p.R454C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.K442N	ACH-000586	Lung Cancer	CCLE	QKENT	DEG_APCC_KENBOX_2	0.7222
p.K442N	NCI-H1876	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.7222
p.R457G	MFE-319	endometrium	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.0833
p.P453L	MCC13	skin	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1944
p.P453S	MCC13	skin	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1944
p.R438C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.R454G	MFE-319	endometrium	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.1667
p.R451C	KNS-62	lung	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.25
p.S447F	SN12C	kidney	COSMIC	QKENT	DEG_APCC_KENBOX_2	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10242	Transcriptional activator Myb	DEG_APCC_KENBOX_2	444:448	QKENT	APC,CDC20,FZR1	0.9949	More...
Q9BSK2	Solute carrier family 25 member 33	DEG_APCC_KENBOX_2	7:11	QKENT	APC,CDC20,FZR1	0.5427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QKENT

Degron related mutations and impact score

Drug responses associated with MYB mutations

All proteins holding degron of QKENT