SLC25A33
UniProt ID: Q9BSK2
Entrez ID: 84275
Protein name: Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not ad...
FUNCTION: Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278). {ECO:0000269|PubMed:14715278, ECO:0000269|PubMed:17596519, ECO:0000269|PubMed:20453889, ECO:0000269|PubMed:25320081}.
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GO - Biological processes (BP):
cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to insulin stimulus [GO:0032869]; mitochondrial genome maintenance [GO:0000002]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial transcription [GO:0006390]; mitochondria-nucleus ...
cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to insulin stimulus [GO:0032869]; mitochondrial genome maintenance [GO:0000002]; mitochondrial respiratory chain complex III assembly [GO:0034551]; mitochondrial transcription [GO:0006390]; mitochondria-nucleus signaling pathway [GO:0031930]; mitochondrion organization [GO:0007005]; positive regulation of cell growth [GO:0030307]; positive regulation of cell population proliferation [GO:0008284]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of oxidative phosphorylation [GO:0002082]; regulation of reactive oxygen species biosynthetic process [GO:1903426]
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GO - Molecular function (MF):
pyrimidine nucleotide transmembrane transporter activity [GO:0015218]...
pyrimidine nucleotide transmembrane transporter activity [GO:0015218]
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GO - Cellular component (CC):
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]...
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]
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SLC25A33
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Kaplan plot for SLC25A33 in
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*NOTE: the Kaplan plots were collected from OncoLnc